Involvement of anoikis-resistance in the metastasis of hepatoma cells
Involvement of anoikis-resistance in the metastasis of hepatoma cells
复制标题
失巢凋亡抵抗参与肝癌细胞的转移。
DOI：
10.1016/j.yexcr.2008.11.010
复制
发表时间：
2009-04-15
影响因子：
3.7
通讯作者：
Sun, Wensheng
中科院分区：
文献类型：
--
作者：
Cao, Lili;Han, Lihui;Sun, Wensheng
获得抗失巢凋亡是癌细胞转移的先决条件。我们已经证明，肝癌细胞可以抵抗失巢凋亡的滑膜样生存方式。在这项研究中，我们进一步表明，获得抗失巢凋亡赋予癌细胞更多的侵袭能力，逃避癌症治疗药物和逃避宿主免疫攻击。我们研究了抗失巢凋亡肝癌细胞对肿瘤坏死因子相关凋亡诱导配体（TRAIL）的反应，TRAIL是一种典型的免疫监视分子，也是一种潜在的抗癌药物。我们的数据表明，分离的肝癌细胞不仅抵抗TRAIL诱导的凋亡，而且还驯化TRAIL发挥隐形的“肿瘤反击”作用。这些结果表明，失巢凋亡抗性的获得可能作为一种选择性压力，使肝癌细胞具有更大的转移潜能，从而促进癌症的发展。(C)2009 Elsevier Inc. All rights reserved.
Acquisition of anoikis-resistance is a pre-requisite for cancer cell metastasis. We have demonstrated that hepatoma cells could resist anoikis by a synoikis-like survival style. In this study, we further suggest that acquisition of anoikis-resistance confer cancer cells more capacity for invasiveness, evading from cancer therapeutic agents and escaping from host immune attacks. We investigated the response of anoikis-resistant hepatoma cells to TNF-related apoptosis-inducing ligand (TRAIL), a typical immune surveillant molecule as well as a potential anticancer agent. Our data indicated that detached hepatoma cells not only resist TRAIL-induced apoptosis, but also domesticate TRAIL to exert a stealth "tumor counterattack" effect. These results reveal that acquisition of anoikis-resistance may act as a selective pressure to superimpose on hepatoma cells more metastatic potential for the development of cancer. (C) 2009 Elsevier Inc. All rights reserved.