Outside the mainstream: novel collecting duct proteins regulating water balance.
Outside the mainstream: novel collecting duct proteins regulating water balance.
复制标题
DOI：
10.1152/ajprenal.00488.2016
复制
发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
S. Rahman;Erika I Boesen
中科院分区：
文献类型：
--
作者：
S. Rahman;Erika I Boesen
身体水分平衡对生存至关重要，因此受到下丘脑和肾脏的严格调控。这一过程中的一个关键机制，精氨酸加压素介导的水通道蛋白2的磷酸化和顶膜插入，已经被广泛研究；然而，随着条件基因敲除动物的增加，最近一些新的收集管蛋白被发现与水的动态平衡有关。在这篇简短的综述中，我们简要讨论了这些新的蛋白质及其在水稳态调节中的作用。
Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.