One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
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一步合成高姜黄素负载量的纳米沸石咪唑酯框架用于治疗宫颈癌
DOI：
10.1021/acsami.5b04315
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发表时间：
2015-10-14
影响因子：
9.5
通讯作者：
Xie, Zhigang
中科院分区：
文献类型：
--
作者：
Zheng, Min;Liu, Shi;Xie, Zhigang
发展了一种简单的纳米沉淀法制备水分散姜黄素（CCM）负载的纳米级咪唑啉骨架-8（CCM@NZIF-8）纳米颗粒（NPs）。所合成的CCM@NZIF-8纳米粒具有高的药物包封率（88.2%）、良好的化学稳定性和在肿瘤酸性微环境中的快速药物释放。共聚焦激光扫描显微镜和细胞毒性实验表明，基于NZIF-8的纳米载体促进CCM的细胞摄取，并导致CCM@NZIF-8对HeLa细胞的细胞毒性高于游离CCM。体内抗癌实验表明，CCM@NZIF-8纳米颗粒表现出比游离CCM高得多的抗肿瘤功效。这项工作突出了使用纳米金属有机框架（NMOFs）作为开发癌症治疗中高效药物递送系统的简单而稳定的平台的潜力。
A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanopartides (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.