Effects of ivabradine on cardiac electrophysiology in dogs with age-related atrial fibrillation.
Effects of ivabradine on cardiac electrophysiology in dogs with age-related atrial fibrillation.
复制标题
伊伐布雷定对年龄相关性心房颤动犬心脏电生理学的影响
DOI：
10.12659/msm.894320
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发表时间：
2015-05-16
期刊：
影响因子：
--
通讯作者：
Tang BP
中科院分区：
文献类型：
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作者：
Li YD;Ji YT;Zhou XH;Jiang T;Hong YF;Li JX;Xing Q;Xiong J;Yusufuaji Y;Tang BP
研究背景伊伐布雷定是一种Na+-K+混合电流抑制剂，可与HCN通道联合收割机结合，降低滑稽电流（If）的跨膜速度，降低心率和心效率，从而用于治疗慢性心力衰竭等心血管疾病。作为一种离子通道阻滞剂，伊伐布雷定也是一种潜在的抗肿瘤药物。材料/方法12只老龄犬（8-10岁）经快速心房起搏2个月，诱发年龄相关性房颤。将犬随机分为伊伐布雷定组和老龄AF组。研究了伊伐布雷定对电生理参数的影响，包括肺静脉和心房的有效不应期（ERP）、AF持续时间和AF诱导率。结果与老年房颤组比较，左上级肺静脉ERP（139.00±4.18 ms vs. 129.00±4.08 ms，P=0.005）（135.00±3.53 ms vs. 122.00±4.47 ms，P=0.001）显著增加，而AF持续时间（46.60±5.07 s vs.205.40 ±1.14 s，P=0.001），房颤诱发率（25%vs.60%，P=0.001）明显降低。结论伊伐布雷定能有效降低房颤的诱发率，可作为预防年龄相关性房颤的上游药物。
Background Ivabradine is an inhibitor of mixed Na+-K+ current that could combine with HCN channels to reduce the transmembrane velocity of funny current (If), heart rate, and cardiac efficiency, and thus be used for the treatment of cardiovascular diseases such as chronic heart failure. As an ion channel blocker, Ivabradine is also a potential antiarrhythmic agent. Material/Methods Twelve aging dogs (8–10 years old) underwent rapid atrial pacing for 2 months to induce age-related AF in this study. The dogs were randomly divided into the Ivabradine group and aging-AF group. The effects of Ivabradine on the electrophysiological parameters, including the effective refractory period (ERP) of the pulmonary veins and atrium, duration of AF, and inducing rate of AF, were investigated. Results As compared to the aging-AF group, the ERPs of the left superior pulmonary vein (139.00±4.18 ms vs. 129.00±4.08 ms, P=0.005) and left auricle (135.00±3.53 ms vs. 122.00±4.47 ms, P=0.001) were significantly increased, while the duration of AF (46.60±5.07 s vs. 205.40±1.14 s, P=0.001) and inducing rate of AF (25% vs. 60%, P=0.001) were significantly decreased. Conclusions Ivabradine could effectively reduce the inducing rate of AF, and thus be used as an upstream drug for the prevention of age-related AF.