Proresolving lipid mediators and mechanisms in the resolution of acute inflammation.
Proresolving lipid mediators and mechanisms in the resolution of acute inflammation.
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DOI：
10.1016/j.immuni.2014.02.009
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发表时间：
2014-03-20
期刊：
影响因子：
32.4
通讯作者：
Serhan, Charles N.
中科院分区：
文献类型：
--
作者：
Buckley, Christopher D.;Gilroy, Derek W.;Serhan, Charles N.
炎症反应，就像所有的生物级联反应一样，是由正反馈和负反馈回路之间的微妙平衡塑造的。现在很明显，除了积极和消极的检查点之外，炎症性级联还出人意料地拥有一个额外的检查点，这是一系列在不损害宿主防御的情况下积极促进分辨率和组织修复的化学物质。事实上，炎症的消退阶段就像它的诱导和抑制一样被积极地编排和精心编排。在这篇综述中，我们探讨了这些omega-3衍生的专门化促分解介质(SPM)的免疫学后果，并讨论了它们在目前所了解的花生四烯酸衍生前列腺素、脂氧素及其天然C15-异构体的作用中的地位。我们建议，炎症的治疗不应局限于急性级联(拮抗)抑制剂的使用，而应扩大到考虑炎症消退阶段诱导剂(激动剂)的巨大治疗潜力。
Inflammatory responses, like all biological cascades, are shaped by a delicate balance between positive and negative feedback loops. It is now clear that in addition to positive and negative checkpoints, the inflammatory cascade rather unexpectedly boasts an additional checkpoint, a family of chemicals that actively promote resolution and tissue repair without compromising host defence. Indeed the resolution phase of inflammation is just as actively orchestrated and carefully choreographed as its induction and inhibition. In this review we explore the immunological consequences of these omega-3-derived specialized pro-resolving mediators (SPMs) and discuss their place within what is currently understood of the role of the arachidonic acid-derived prostaglandins, lipoxins and their natural C15-epimers. We propose that treatment of inflammation should not be restricted to the use of inhibitors of the acute cascade (antagonism) but broadened to take account of the enormous therapeutic potential of inducers (agonists) of the resolution phase of inflammation.
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影响因子：
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作者：
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影响因子：
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作者：
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Serhan, Charles N.
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DOI：
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发表时间：
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期刊：
Critical care (London, England)
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DOI：
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发表时间：
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影响因子：
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作者：
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