Co-circulation of two genotypes of measles virus and mutual change of the prevailing genotypes every few years in Osaka, Japan
Co-circulation of two genotypes of measles virus and mutual change of the prevailing genotypes every few years in Osaka, Japan
复制标题
DOI：
10.1002/jmv.10278
复制
发表时间：
2003-02-01
影响因子：
12.7
通讯作者：
Seto, Y
中科院分区：
文献类型：
--
作者：
Kubo, H;Iritani, N;Seto, Y
对19972001年从日本大坂分离的44株麻疹野病毒（MV）进行了基因分型，并与世界卫生组织（WHO）指定的MV参考株进行了系统发育分析。野生型MV菌株被分为两种基因型，D3和D5，被认为是日本本土的。1997年分离的12株中有6株为D3基因型，6株为D5基因型。1998年13株菌中11株为D3型，2株为D5型。1999年没有麻疹流行，也没有分离出任何菌株。2000年10株中有9株为D5基因型，1株为D3基因型，2001年9株为D5基因型。这些结果表明，除了2001年，在大坂，分类为基因型D3和D5的野生型MV株系共循环，而MV基因型没有完全改变。此外，1998年和2000-2001年之间的流行基因型是不同的。结合1993-1995年有关该地区MV基因型的报道，这些结果表明，在日本大坂，流行的野生型MV基因型在D3和D5之间每隔几年就会发生相互变化。
Genotypes of 44 wild-type measles virus (MV) strains isolated in Osaka, Japan, during 19972001, were determined based on phylogenetic analyses of a 456-nt 3' terminal nucleoprotein gene sequence with the reference MV strains designated by the World Health Organization. The wild-type MV strains were classified into two genotypes, D3 and D5, recognized as indigenous in Japan. Six of 12 strains isolated in 1997 were classified into genotype D3 and the other 6 into D5. Eleven of 13 strains were D3, and 2 were D5 in 1998. There were no measles epidemics, and no strains were isolated in 1999. Nine of 10 strains were genotype D5, and only one was D3 in 2000, and 9 of 9 were D5 in 2001. These results indicate that the wild-type MV strains classified into genotypes D3 and D5 co-circulated without the complete change of the MV genotype in Osaka, except in 2001. Furthermore, the prevailing genotype was different between 1998 and 2000-2001. Together with a previous report about MV genotype in this area during 1993-1995, these results suggest that the mutual change of the prevailing wild-type MV genotypes between D3 and D5 occurs every few years in Osaka, Japan.