Characteristics of patients with late onset systemic lupus erythematosus in Turkey
Characteristics of patients with late onset systemic lupus erythematosus in Turkey
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DOI：
10.1111/j.1742-1241.2004.00283.x
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发表时间：
2005-02-01
影响因子：
2.6
通讯作者：
Konice, M
中科院分区：
文献类型：
--
作者：
Sayarlioglu, M;Cefle, A;Konice, M
系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，主要影响年轻女性。在本研究中，我们旨在调查发病年龄大于或等于50岁的SLE患者的临床、实验室和管理特征。根据首次SLE相关症状，从记录中确定20例迟发性SLE患者（≥50岁）（I组）。同时选取连续100例50岁前首发症状的SLE患者作为对照（第二组）。按照预先设定的方案记录患者的临床、实验室和管理特征，并采用chi(2)、Student’st检验和Fisher’s精确检验进行比较。I组（F/M: 18/2）和II组（F/M: 90/10）的人口学结果比较如下：平均发病年龄分别为53.9 +/- 4.5岁和26.3 +/- 9.2岁，平均随访时间分别为44.2 +/- 40.5个月和50.1 +/- 47.4个月，平均损伤指数分别为0.6 +/- 0.6和0.58 +/- 1.4。两组在临床、实验室参数、损伤指数及免疫抑制治疗特点方面均无显著差异。除发热外，两组sle相关表现相似（I组为10%，II组为41%，p = 0.01）。组中仅有2例出现肺纤维化（p = 0.027）。起病年龄大于或等于50岁的SLE患者的临床和实验室特征及疾病结局与起病年龄较小的对照SLE患者无显著差异。
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder mainly affecting young women. In this study, we aimed at investigating the clinical, laboratory and management characteristics of our SLE patients with an age of onset greater than or equal to50.Twenty patients with late onset SLE (greater than or equal to50 years) were identified from the records, on the basis of their first SLE-related symptoms (Group I). A hundred consecutive SLE patients with initial symptoms before the age of 50 were also selected as controls (Group II). Clinical, laboratory and management characteristics of the patients were recorded according to pre-defined protocol and compared by chi(2), Student's t-test and Fisher's exact test.Comparison of the demographic findings between the Group I (F/M: 18/2) and the Group II (F/M: 90/10) were as follows: the mean age of disease onset was 53.9 +/- 4.5 years vs. 26.3 +/- 9.2 years, mean time of follow-up was 44.2 +/- 40.5 months vs. 50.1 +/- 47.4 months, mean damage index was 0.6 +/- 0.6 vs. 0.58 +/- 1.4. There was no significant difference between the two groups with regard to clinical, laboratory parameters, damage index and immunosuppressive treatment characteristics. SLE-related manifestations were similar in two groups except fever (10% in the Group I vs. 41% in the Group II; p = 0.01). The only two patients with pulmonary fibrosis were found in the Group I (p = 0.027).The clinical and laboratory characteristics and the disease outcome in SLE patients with an age of onset greater than or equal to50 years did not show significant differences from the control SLE patients with a younger age of onset.