Nipah virus encephalitis outbreak in Malaysia
Nipah virus encephalitis outbreak in Malaysia
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DOI：
10.1086/338818
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发表时间：
2002-05-01
影响因子：
11.8
通讯作者：
Chua, KB
中科院分区：
文献类型：
--
作者：
Lam, SK;Chua, KB
涉及人畜共患病的新发传染病已成为重要的全球卫生问题。1998年马来西亚由一种新出现的副粘病毒尼帕病毒引起的养猪户严重发热性脑炎的暴发就是一个很好的例子。这种疾病有可能通过受感染的动物传播到其他国家，并可能造成相当大的经济损失。临床表现包括节段性肌阵挛、反射不全、高血压和心动过速，组织学证据包括脑和其他主要器官的内皮损伤和血管炎。磁共振成像显示存在弥漫在大脑各处的离散高信号病变。尼帕病毒在Vero细胞中引起合体形成，与Hendra病毒有抗原性关系。岛飞狐(Pteropus lowomelanus；果蝠)可能是这种病毒的宿主。马来西亚的疫情通过扑杀100万头猪得到控制。
Emerging infectious diseases involving zoonosis have become important global health problems. The 1998 outbreak of severe febrile encephalitis among pig farmers in Malaysia caused by a newly emergent paramyxovirus, Nipah virus, is a good example. This disease has the potential to spread to other countries through infected animals and can cause considerable economic loss. The clinical presentation includes segmental myoclonus, areflexia, hypertension, and tachycardia, and histologic evidence includes endothelial damage and vasculitis of the brain and other major organs. Magnetic resonance imaging has demonstrated the presence of discrete high-signal-intensity lesions disseminated throughout the brain. Nipah virus causes syncytial formation in Vero cells and is antigenically related to Hendra virus. The Island flying fox (Pteropus hypomelanus; the fruit bat) is a likely reservoir of this virus. The outbreak in Malaysia was controlled through the culling of >1 million pigs.