Affective neural circuitry during facial emotion processing in pediatric bipolar disorder
Affective neural circuitry during facial emotion processing in pediatric bipolar disorder
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DOI：
10.1016/j.biopsych.2006.07.011
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发表时间：
2007-07-15
影响因子：
10.6
通讯作者：
Sweeney, John A.
中科院分区：
文献类型：
--
作者：
Pavuluri, Mani N.;O'Connor, Megan Marlow;Sweeney, John A.
背景：面部情绪是人类互动的核心。识别支持面部情绪评估能力的情感处理电路中的病理生理学可能有助于理解儿童双相情感障碍中的情感调节。方法：10例胸腺功能正常、未用药的儿童双相情感障碍患者和10例年龄、性别、种族、社会经济地位和智商相匹配的健康对照者进行功能磁共振成像扫描。愤怒、快乐和中性的脸被呈现在30秒的区块中，区块之间有20秒的休息时间。受试者被要求按下一个按钮时，每个面孔出现，以确保注意力保持在task.Results：在双相情感障碍患者中，在响应愤怒和快乐的面孔相对于中性的面孔，我们观察到右吻腹外侧前额叶皮层的激活减少，右前膝前扣带回，杏仁核和边缘皮层的活动增加。双相情感障碍患者还表现出减少激活枕叶皮层的视觉区域，以及更高层次的视觉感知领域，包括上级颞上沟和梭状回愤怒的面孔和后顶叶皮层与快乐的faces.Conclusions：研究结果文件的情感神经回路在儿科双相情感障碍的障碍。腹外侧前额叶皮层的激活减少可能反映了自上而下的控制减少，导致杏仁核和边缘核区域的过度激活。枕叶区的变化可能代表了当对面部的情感反应不能被成功调制时，控制感官输入的努力。情感处理回路的紊乱可能会导致双相情感障碍和社会认知困难。
Background: Facial emotions are central to human interaction. Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder.Methods: Ten euthymic, unmedicated pediatric bipolar patients and 10 healthy control subjects matched for age, gender, race, socioeconomic status, and IQ were scanned with functional magnetic resonance imaging. Angry, happy, and neutral faces were presented in 30-sec blocks, with a 20-sec rest period between blocks. Subjects were asked to press a button when each face appeared, to ensure that attention was maintained on-task.Results: In bipolar patients, in response to both angry and happy faces relative to neutral faces, we observed reduced activation of right rostral ventrolateral prefrontal cortex together with increased activity in right pregenual anterior cingulate, amygdala, and paralimbic cortex. Bipolar patients also showed reduced activation of visual areas in occipital cortex together with greater activation in higher-order visual perceptual areas, including superior temporal sulcus and fusiform gyrus with angry faces and posterior parietal cortex with happy faces.Conclusions: Findings document a disturbance in affective neurocircuitry in pediatric bipolar disorder. Reduced activation in ventrolateral prefrontal cortex might reflect diminished top-down control that leads to the observed exaggerated activation in amygdala and paralimbic areas. Changes in occipital areas might represent an effort to gate sensory input when affective responses to the faces could not be successfully modulated. Disturbances in affect processing circuitry could contribute to emotional dysregulation and social cognitive difficulties in bipolar youth.