Can saliva offer an advantage in monitoring of diabetes mellitus? - A case control study.
Can saliva offer an advantage in monitoring of diabetes mellitus? - A case control study.
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DOI：
10.4317/jced.51386
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发表时间：
2014-10
影响因子：
--
通讯作者：
Fazil AK
中科院分区：
文献类型：
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作者：
Balan P;Babu SG;Sucheta KN;Shetty SR;Rangare AL;Castelino RL;Fazil AK
目的：糖尿病是近年来出现的一大健康问题。目前静脉穿刺法监测血糖的方法是有创的，导致患者依从性降低，从而导致监测不准确。本研究的目的是对2型糖尿病患者的唾液血糖和血糖浓度进行对比分析。研究设计：本研究采用葡萄糖氧化酶法测定了90名受试者的血液和非刺激性唾液中的血糖水平，将受试者分为控制的2型糖尿病组、未控制的2型糖尿病组和非糖尿病组。统计分析采用单因素方差分析、后处理Tukey检验和皮尔逊相关系数检验。结果：糖尿病患者的唾液血糖水平明显高于对照组。糖尿病患者唾液与血糖水平呈显著正相关。结论：糖尿病患者唾液中的葡萄糖浓度较高，但高血糖不影响唾液中的血糖水平。需要进一步澄清才能声称唾液对糖尿病的诊断潜力。关键词：唾液葡萄糖、2型糖尿病、血糖。
Objectives: Diabetes Mellitus is emerging as a major health problem over these years. Present method of blood glucose monitoring by venepuncture is invasive leading to reduced patient compliance and thereby ineffective judicious monitoring. The need of the hour is to direct research in the direction of establishing painless and more acceptable blood glucose analysis method.The objective of the study is to conduct a comparative analysis of the concentrations of salivary glucose and blood glucose in type 2 diabetes mellitus patients. Study Design: This study assessed glucose levels using the glucose oxidase method in blood and unstimulated saliva in 90 subjects who were divided into 3 equal groups of controlled type 2 diabetes, uncontrolled type 2 diabetes and those without diabetes. Statistical analysis was carried out using one way ANOVA, Post hoc Tukeys tests and Pearson’s correlation coefficient test. Results: Salivary glucose levels were significantly higher in patients with diabetes than controls. There was a significant positive correlation between salivary and plasma glucose levels in patients with diabetes. Conclusions: Glucose concentration in saliva is higher in diabetics but hyperglycemia does not influence salivary glucose levels. Further clarification is required to claim the diagnostic potentials of saliva in diabetes. Key words:Salivary glucose, type 2 diabetes mellitus, blood glucose.