CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering.
CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering.
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DOI：
10.1093/nar/gkm953
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Craik DJ
中科院分区：
文献类型：
--
作者：
Wang CK;Kaas Q;Chiche L;Craik DJ
CyBase最初是作为骨架环化蛋白的数据库开发的，提供序列、结构和功能数据的搜索和显示功能。环状蛋白很有趣，因为与传统蛋白相比，它们具有更高的稳定性和更强的结合亲和力，因此可能被开发为蛋白质药物。新的CyBase版本的特点是重新设计了界面和内部架构，以提高用户交互性，与最初的版本相比，整理的数据量增加了一倍，并提供了一套新的工具，可用于环状蛋白的可视化、表征和工程。这些工具包括序列/结构2D表示，合成类似物的接枝和突变研究总结，已知蛋白质结构中N-到c端距离的研究以及预测最佳连接器长度的结构建模工具。这些更新是有用的，因为它们有可能帮助加速发现天然存在的环蛋白和环蛋白药物的工程。CyBase的新版本可在http://research1t.imb.uq.edu.au/cybase上获得
CyBase was originally developed as a database for backbone-cyclized proteins, providing search and display capabilities for sequence, structure and function data. Cyclic proteins are interesting because, compared to conventional proteins, they have increased stability and enhanced binding affinity and therefore can potentially be developed as protein drugs. The new CyBase release features a redesigned interface and internal architecture to improve user-interactivity, collates double the amount of data compared to the initial release, and hosts a novel suite of tools that are useful for the visualization, characterization and engineering of cyclic proteins. These tools comprise sequence/structure 2D representations, a summary of grafting and mutation studies of synthetic analogues, a study of N- to C-terminal distances in known protein structures and a structural modelling tool to predict the best linker length to cyclize a protein. These updates are useful because they have the potential to help accelerate the discovery of naturally occurring cyclic proteins and the engineering of cyclic protein drugs. The new release of CyBase is available at http://research1t.imb.uq.edu.au/cybase
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DOI：
10.1073/pnas.0504613102
发表时间：
2005-09-27
影响因子：
11.1
作者：
Clark, RJ;Fischer, H;Craik, DJ
通讯作者：
Craik, DJ
影响因子：
5.6
作者：
Craik, DJ;Daly, NL;Waine, C
通讯作者：
Waine, C
影响因子：
2.9
作者：
Hill, JM;Oomen, CJ;Craik, DJ
通讯作者：
Craik, DJ
影响因子：
14.9
作者：
Mulvenna JP;Wang C;Craik DJ
通讯作者：
Craik DJ
DOI：
10.1073/pnas.0409114102
发表时间：
2005-01-25
影响因子：
11.1
作者：
Krishna, MMG;Englander, SW
通讯作者：
Englander, SW