Sun exposure and prostate cancer risk: Evidence for a protective effect of early-life exposure
Sun exposure and prostate cancer risk: Evidence for a protective effect of early-life exposure
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DOI：
10.1158/1055-9965.epi-06-1053
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发表时间：
2007-06-01
影响因子：
3.8
通讯作者：
Schwartz, Gary G.
中科院分区：
文献类型：
--
作者：
John, Esther M.;Koo, Jocelyn;Schwartz, Gary G.
越来越多的实验和流行病学证据支持维生素 D 可降低前列腺癌风险的假设。一些证据表明，前列腺癌的风险可能会受到生命早期阳光照射的影响。我们分析了国家健康和营养检查调查 I 流行病学随访研究的数据，以检查前列腺癌风险与早期和成人居住阳光照射以及通过自我报告、医生报告和皮肤科检查评估的成人阳光照射之间的关联。我们使用出生时的太阳辐射来衡量生命早期的阳光照射情况。从 1971 年到 1975 年（基线）到 1992 年的随访，在可获得日光照射数据的非西班牙裔白人中发现了 161 例前列腺癌病例（102 例非致命性，59 例致命）。研究发现，出生在高太阳辐射地区的男性存在显着的负相关关系（高太阳辐射与低太阳辐射的相对风险为 0.49，95% 置信区间为 0.27-0.90），致命性前列腺癌的降低幅度略高于非致命性前列腺癌。成年期频繁的娱乐性阳光照射仅与致命性前列腺癌风险显着降低相关（相对风险，0.47；95% 置信区间，0.23-0.99）。这些发现表明，除了成年期的阳光照射之外，生命早期的阳光照射也可以预防前列腺癌。
Mounting experimental and epidemiologic evidence supports the hypothesis that vitamin D reduces the risk of prostate cancer. Some evidence suggests that prostate cancer risk may be influenced by sun exposure early in life. We analyzed data from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study to examine associations of prostate cancer risk with early-life and adult residential sun exposure and adult sun exposures that were assessed through self-report, physician report, and dermatologic examination. We used solar radiation in the state of birth as a measure of sun exposure in early life. Follow-up from 1971 to 1975 (baseline) to 1992 identified 161 prostate cancer cases (102 nonfatal and 59 fatal) among non-Hispanic white men for whom sun exposure data were available. Significant inverse associations were found for men born in a region of high solar radiation (relative risk, 0.49, 95% confidence interval, 0.27-0.90 for high versus low solar radiation), with a slightly greater reduction for fatal than for nonfatal prostate cancer. Frequent recreational sun exposure in adulthood was associated with a significantly reduced risk of fatal prostate cancer only (relative risk, 0.47; 95% confidence interval, 0.23-0.99). These findings suggest that, in addition to sun exposure in adulthood, sun exposure in early life protects against prostate cancer.