Growing thin - How bulk lipid transport drives expansion of the autophagosome membrane but not of its lumen.
Growing thin - How bulk lipid transport drives expansion of the autophagosome membrane but not of its lumen.
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DOI：
10.1016/j.ceb.2023.102190
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发表时间：
2023-06
影响因子：
7.5
通讯作者：
T. Melia
中科院分区：
文献类型：
--
作者：
T. Melia
大型自噬的关键事件是一种名为自噬小体的新细胞器的新形成，当自噬小体完成时，将在其双膜结构中捕获少量细胞质。最终与溶酶体的融合允许这种捕获的物质被降解回简单的分子，这些分子可以在饥饿期间回收利用以支持细胞功能。自噬是如何形成的，60多年来一直是一个具有挑战性的问题。这篇综述重点介绍了形成自噬体膜扩张模型的基础工作，该模型建立在蛋白质介导的脂质运输的基础上。
The key event in macroautophagy is thede novoformation of a new organelle called the autophagosome which when complete, will have captured bits of cytoplasm within its double-membrane structure. Eventual fusion with the lysosome allows this captured material to be degraded back to simple molecules which can be recycled to support cell function during starvation. How autophagosomes form has been a challenging question for over 60 years. This review highlights work that forms the basis for an autophagosome membrane expansion model grounded in protein-mediated lipid transport.