The emerging role of zinc transporters in cellular homeostasis and cancer.
The emerging role of zinc transporters in cellular homeostasis and cancer.
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DOI：
10.1038/sigtrans.2017.29
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发表时间：
2017
影响因子：
39.3
通讯作者：
Dempski RE
中科院分区：
文献类型：
--
作者：
Bafaro E;Liu Y;Xu Y;Dempski RE
锌是一种必需的微量营养素，在许多细胞蛋白质的结构或酶功能中发挥作用。细胞锌稳态涉及两个家族的金属转运蛋白的相反作用：ZnT（SLC30）家族，其功能是降低细胞质锌浓度和ZIP（SLC39）家族，其功能是增加细胞质锌浓度。由这些转运蛋白家族介导的细胞内锌水平的波动影响参与正常细胞发育、生长、分化和死亡的信号通路。因此，锌转运蛋白定位和功能的变化导致锌稳态异常具有病理生理效应。锌稳态异常与癌症的进展有关。在这里，我们回顾了最近的进展，了解锌转运的ZnT和ZIP家族蛋白的结构基础，以及强调锌作为一种信号分子在生理条件下，在各种癌症中的作用。随着锌在癌症的发展和进展中成为重要的信号分子，调节细胞锌稳态的ZnT和ZIP转运蛋白是靶向癌症治疗的有希望的候选者。
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of many cellular proteins. Cellular zinc homeostasis involves the opposing action of two families of metal transporters: the ZnT (SLC30) family that functions to reduce cytoplasmic zinc concentrations and the ZIP (SLC39) family that functions to increase cytoplasmic zinc concentrations. Fluctuations in intracellular zinc levels mediated by these transporter families affect signaling pathways involved in normal cell development, growth, differentiation and death. Consequently, changes in zinc transporter localization and function resulting in zinc dyshomeostasis have pathophysiological effects. Zinc dyshomeostasis has been implicated in the progression of cancer. Here we review recent progress toward understanding the structural basis for zinc transport by ZnT and ZIP family proteins, as well as highlight the roles of zinc as a signaling molecule in physiological conditions and in various cancers. As zinc is emerging as an important signaling molecule in the development and progression of cancer, the ZnT and ZIP transporters that regulate cellular zinc homeostasis are promising candidates for targeted cancer therapy.
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影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
DOI：
10.1016/j.urolonc.2010.11.010
发表时间：
2012-11-01
影响因子：
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发表时间：
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影响因子：
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影响因子：
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