Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links With Pragmatic Language
Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links With Pragmatic Language
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DOI：
10.1352/1944.7558-118.6.475
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发表时间：
2013-11-01
影响因子：
2.1
通讯作者：
Losh, Molly
中科院分区：
文献类型：
--
作者：
Klusek, Jessica;Martin, Gary E.;Losh, Molly
这项研究检验了以下假设：语用（即社交）语言障碍与自闭症谱系障碍 (ASD) 和脆性 X 综合征 (FXS) 的唤醒失调有关。 40 名患有自闭症谱系障碍 (ASD) 的男孩、39 名患有 FXS 的男孩和 27 名患有典型发育 (TD) 的男孩参与其中，年龄为 4-15 岁。与患有 TD 的男孩相比，患有 FXS 的男孩更加兴奋，但与患有 ASD 的男孩没有差异。迷走神经张力减弱预示着自闭症谱系障碍的语用障碍，并且不同群体的心脏活动和接受/表达词汇之间出现了关联。研究结果支持自主神经功能障碍是 ASD 语用障碍的潜在机制，并表明 ASD 和 FXS 具有相同的生物生理特征，这对于理解脆性 X 智力低下 1（FMR1，FXS 基因）在 ASD 病理生理学中的作用具有重要意义。
This study tested the hypothesis that pragmatic (i.e., social) language impairment is linked to arousal dysregulation in autism spectrum disorder (ASD) and fragile X syndrome (FXS). Forty boys with ASD, 39 with FXS, and 27 with typical development (TD), aged 4-15 years, participated. Boys with FXS were hyperaroused compared to boys with TD but did not differ from boys with ASD. Dampened vagal tone predicted pragmatic impairment in ASD, and associations emerged between cardiac activity and receptive/expressive vocabulary across groups. Findings support autonomic dysfunction as a mechanism underlying pragmatic impairment in ASD and suggest that biophysiological profiles are shared in ASD and FXS, which has implications for understanding the role of fragile X mental retardation-1 (FMR1, the FXS gene) in the pathophysiology of ASD.