BONE-MARROW INVOLVEMENT IN EPITHELIAL OVARIAN-CANCER BY IMMUNOCYTOCHEMICAL ASSESSMENT
BONE-MARROW INVOLVEMENT IN EPITHELIAL OVARIAN-CANCER BY IMMUNOCYTOCHEMICAL ASSESSMENT
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DOI：
10.1016/0090-8258(90)90088-3
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发表时间：
1990-09-01
影响因子：
4.7
通讯作者：
LIVINGSTON, RB
中科院分区：
文献类型：
--
作者：
CAIN, JM;ELLIS, GK;LIVINGSTON, RB
上皮性卵巢癌骨髓受累的发生率已被评估为自体骨髓支持的持续关注。50例患者获得58个抽吸物，53个抽吸物可评价。用单克隆细胞角蛋白抗体35βH11和34βE12进行免疫细胞化学。没有并发症。12例（23%）为阳性，3例不确定。两组患者的分期、分级、CA-125水平无差异。在初步诊断时，没有患者活检呈阳性。大多数患者来自二次探查手术;其中，19例患者中有7例为阳性。12例抽吸阳性患者中有5例死于疾病，而38例抽吸阴性患者中有5例死于疾病，抽吸阳性患者的总生存时间更长，直至死于疾病。我们可以确认23%的患者在疾病过程中的不同时间存在上皮性卵巢癌。我们无法确定这一发现的风险因素，也无法确定在该数据集中发现的这些细胞的活力。
The incidence of bone marrow involvement with epithelial ovarian cancer has been evaluated as a continuation of interest in autologous bone marrow support. Fifty-eight aspirates were obtained on 50 patients and 53 aspirates were evaluable. Immunocytochemistry with the monoclonal cytokeratin antibodies 35βH11 and 34βE12 was performed. There have been no complications. Twelve (23%) were positive and three were indeterminate. Stage, grade, and CA-125 level were not different in the two groups. No patient had a positive biopsy at the time of initial diagnosis. The majority of patients were drawn from second-look procedures; of these, 7 of 19 were positive. Five of twelve with positive aspirates died from disease versus 5 of 38 with negative aspirates, and patients with a positive aspirate had a longer overall survival time until death from disease. We can confirm the presence of epithelial ovarian cancer in 23% of patients at varying times in the course of their disease. We cannot identify risk factors for the development of this finding nor the viability of those cells when found in this data set.