The use of gold nanoparticles to enhance radiotherapy in mice
The use of gold nanoparticles to enhance radiotherapy in mice
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DOI：
10.1088/0031-9155/49/18/n03
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发表时间：
2004-09-21
影响因子：
3.5
通讯作者：
Smilowitz, HM
中科院分区：
文献类型：
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作者：
Hainfeld, JF;Slatkin, DN;Smilowitz, HM
携带皮下EMT-6乳腺癌的小鼠接受单次静脉内注射1.9 nm直径的金颗粒（高达2.7 g Au/kg体重），其将肿瘤中的金浓度升高至7 mg Au/g。在几分钟的250 kVp X射线治疗中，肿瘤与正常组织的金浓度比保持在8：1。一年生存率为86%，而单独使用X射线的一年生存率为20%，单独使用金的一年生存率为0%。安全消融肿瘤的增加取决于注入的金的量。金纳米颗粒对小鼠显然是无毒的，并且大部分通过肾脏从体内清除。这种新颖的使用小的金纳米粒子允许实现显着的高Z放射增强所需的肿瘤中的高金属含量。
Mice bearing subcutaneous EMT-6 mammary carcinomas received a single intravenous injection of 1.9 nm diameter gold particles (up to 2.7 g Au/kg body weight), which elevated concentrations of gold to 7 mg Au/g in tumours. Tumour-to-normal-tissue gold concentration ratios remained similar to8:1 during several minutes of 250 kVp x-ray therapy. One-year survival was 86% versus 20% with x-rays alone and 0% with gold alone. The increase in tumours safely ablated was dependent on the amount of gold injected. The gold nanoparticles were apparently non-toxic to mice and were largely cleared from the body through the kidneys. This novel use of small gold nanoparticles permitted achievement of the high metal content in tumours necessary for significant high-Z radioenhancement.