ADIPONECTIN IN FRESH FROZEN PLASMA CONTRIBUTES TO RESTORATION OF VASCULAR BARRIER FUNCTION AFTER HEMORRHAGIC SHOCK
ADIPONECTIN IN FRESH FROZEN PLASMA CONTRIBUTES TO RESTORATION OF VASCULAR BARRIER FUNCTION AFTER HEMORRHAGIC SHOCK
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DOI：
10.1097/shk.0000000000000458
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发表时间：
2016-01-01
期刊：
影响因子：
3.1
通讯作者：
Ko, Tien C.
中科院分区：
文献类型：
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作者：
Deng, Xiyun;Cao, Yanna;Ko, Tien C.
失血性休克是平民和军人创伤中可预防死亡的主要原因。在需要大量输血的患者中使用新鲜冰冻血浆（FFP）可以改善预后。 FFP 含有大量脂联素，已知其具有血管保护功能。我们假设 FFP 主要通过脂联素改善血管屏障功能。对 19 名失血性休克 (HS) 重伤患者的血浆脂联素水平进行了测量。与正常人相比，HS患者复苏前血浆脂联素水平下降至49%（P
Hemorrhagic shock is the leading cause of preventable deaths in civilian and military trauma. Use of fresh frozen plasma (FFP) in patients requiring massive transfusion is associated with improved outcomes. FFP contains significant amounts of adiponectin, which is known to have vascular protective function. We hypothesize that FFP improves vascular barrier function largely via adiponectin. Plasma adiponectin levels were measured in 19 severely injured patients in hemorrhagic shock (HS). Compared with normal individuals, plasma adiponectin levels decreased to 49% in HS patients before resuscitation (P