A comparison of morphine analgesic tolerance in male and female mice
A comparison of morphine analgesic tolerance in male and female mice
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DOI：
10.1016/s0006-8993(00)02685-8
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发表时间：
2000-10-06
期刊：
影响因子：
2.9
通讯作者：
Hopkins, E
中科院分区：
文献类型：
--
作者：
Kest, B;Palmese, C;Hopkins, E
比较雄性和雌性吗啡耐受性的研究很少，迄今为止的所有研究都使用大鼠。从大鼠的研究结果中概括，使用缩尾试验在雄性和雌性小鼠中研究了吗啡耐受性。3天和7天的全身吗啡注射产生了显着的，但不平等的吗啡剂量-反应曲线，使女性表现出更大的增加镇痛ED 50值相比，男性。在一项单独的实验中，当比较吗啡给药3天后的%MPE（最大可能效应）和%总（曲线下面积）时，雄性和雌性显示出吗啡镇痛敏感性的相似降低。在两项研究中均未观察到性别之间初始吗啡敏感性的差异。数据表明，与大鼠相比，雌性小鼠在慢性吗啡给药后，吗啡镇痛作用相对于雄性小鼠降低更大，但这种性别差异可能取决于评估镇痛作用的方法。此外，吗啡治疗的持续时间和/或累积剂量不影响吗啡耐受性的性别差异的表达。(C)2000 Elsevier Science B. V.保留所有权利。
Studies comparing morphine tolerance in males and females are rare, and all studies to date have utilized the rat. To generalize from findings with rats morphine tolerance was investigated in male and female mice using the tail-withdrawal test. Three and 7 days of systemic morphine injections produced significant but unequal rightward shifts in the morphine dose-response curve such that females displayed greater increases in analgesic ED50 values when compared to males. In a separate experiment, males and females displayed similar reductions in morphine analgesic sensitivity when %MPE (maximum possible effect) and %total (area under the curve) were compared after 3 days of morphine. Differences in initial morphine sensitivity between sexes were not observed in either study. The data demonstrate that, in contrast to rats, female mice undergo greater reductions in morphine analgesia relative to males following chronic morphine, but this sex difference may depend on the method of assessing analgesia. Furthermore, the duration and/or cumulative dose of morphine treatment does not affect the expression of sex differences in morphine tolerance. (C) 2000 Elsevier Science B.V. All rights reserved.