Magnetic resonance spectroscopy investigations of functionally defined language areas in schizophrenia patients with and without auditory hallucinations
Magnetic resonance spectroscopy investigations of functionally defined language areas in schizophrenia patients with and without auditory hallucinations
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DOI：
10.1016/j.neuroimage.2014.03.009
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发表时间：
2014-07-01
期刊：
影响因子：
5.7
通讯作者：
Kreis, Roland
中科院分区：
文献类型：
--
作者：
Homan, Philipp;Vermathen, Peter;Kreis, Roland
背景：精神障碍中发生的脑功能障碍可以表现出仅限于有限大脑区域的代谢紊乱。幻听已被证明与与特定语言功能相关的特定皮质区域有关。在这里，我们调查了幻听代谢变化的研究是否需要对其位置和大小进行功能性而非解剖学定义，以便通过磁共振波谱 (MRS) 进行可靠的研究。方法：有幻听的精神分裂症患者 (AH; n = 12) 和无幻听的患者 (NH; n = 8) 以及健康对照者 (HC; n = 11) 在功能 MRI (fMRI) 中接受言语流利性任务，以功能性地定义布洛卡的和韦尼克区。左、右 Heschl 回在解剖学上进行了定义。结果：对于 Broca 区，fMRI 定义的区域与相应的解剖学定义区域之间的自然空间平均距离分别为 12.4 +/- 6.1 mm（范围：2.7-36.1 mm），对于 Wernicke 区，分别为 16.8 +/- 6.2 mm（范围：4.5-26.4 mm）。因此，空间方差与研究区域的大小具有相似的程度。将研究分为额叶脑中的单个体素检查和更均匀场区域的光谱成像部分，几乎所有光谱都获得了良好的光谱质量。在布罗卡区，NH 中的 N-乙酰基天冬氨酸 (NAA) 水平低于 HC (p = 0.02)，因此存在显着的群体效应 (p = 0.03)。左侧 Heschl 回的 NAA 水平与 PANSS 总分（p = 0.03）和负分（p = 0.006）呈正相关。在布罗卡区，肌醇水平与 PANSS 总分呈负相关（p = 0.008）。 结论：这项研究仅支持额叶区的精神分裂症神经退行性假说，而从颞区获得的结果与大多数先前的研究形成鲜明对比。未来的研究应该检验本研究提出的假设，即如果预计神经化学失衡仅限于功能灶，则需要对语言区域进行功能定义。 (C) 2014 Elsevier Inc. 保留所有权利。
Background: Cerebral dysfunction occurring in mental disorders can show metabolic disturbances which are limited to circumscribed brain areas. Auditory hallucinations have been shown to be related to defined cortical areas linked to specific language functions. Here, we investigated if the study of metabolic changes in auditory hallucinations requires a functional rather than an anatomical definition of their location and size to allow a reliable investigation by magnetic resonance spectroscopy (MRS).Methods: Schizophrenia patients with (AH; n = 12) and without hallucinations (NH; n = 8) and healthy controls (HC; n = 11) underwent a verbal fluency task in functional MRI (fMRI) to functionally define Broca's and Wernicke's areas. Left and right Heschl's gyri were defined anatomically.Results: The mean distances in native space between the fMRI-defined regions and a corresponding anatomically defined area were 12.4 +/- 6.1 mm (range: 2.7-36.1 mm) for Broca's area and 16.8 +/- 6.2 mm (range: 4.5-26.4 mm) for Wernicke's area, respectively. Hence, the spatial variance was of similar extent as the size of the investigated regions. Splitting the investigations into a single voxel examination in the frontal brain and a spectroscopic imaging part for the more homogeneous field areas led to good spectral quality for almost all spectra. In Broca's area, there was a significant group effect (p = 0.03) with lower levels of N-acetyl-aspartate (NAA) in NH compared to HC (p = 0.02). There were positive associations of NAA levels in the left Heschl's gyrus with total (p = 0.03) and negative (p = 0.006) PANSS scores. In Broca's area, there was a negative association of myo-inositol levels with total PANSS scores (p = 0.008).Conclusion: This study supports the neurodegenerative hypothesis of schizophrenia only in a frontal region whereas the results obtained from temporal regions are in contrast to the majority of previous studies. Future research should test the hypothesis raised by this study that a functional definition of language regions is needed if neurochemical imbalances are expected to be restricted to functional foci. (C) 2014 Elsevier Inc. All rights reserved.