B-lymphocyte alloantigens associated with systemic lupus erythematosus.
B-lymphocyte alloantigens associated with systemic lupus erythematosus.
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与系统性红斑狼疮相关的 B 淋巴细胞同种抗原。
DOI：
10.1056/nejm197809072991004
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
D. Mann
中科院分区：
文献类型：
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作者：
J. Reinertsen;J. Klippel;A. Johnson;A. Steinberg;J. Decker;D. Mann
我们检测了41例系统性红斑狼疮患者和184名对照者的B淋巴细胞同种异体抗原，使用了一组47份妊娠血清，并比较了个体血清的反应频率。一种血清la-715与75.6%的患者和14.1%的对照组的B淋巴细胞反应（Pc小于0.005，相对危险度18.8）。其中28名患者还使用第七届国际组织相容性研讨会的一组HLA-D相关血清进行了分型，分配了HLA-DRw类型，并与490名研讨会对照进行了比较。系统性红斑狼疮患者HLA-DRw 2（57.1%对26.4%，Pc小于0.004）和HLA-DRw 3（46.4%对22.2%，Pc小于0.03）均升高。这项研究表明，选择B淋巴细胞同种抗原，这是由主要组织相容性复合体的基因控制，是目前在系统性红斑狼疮的频率增加。
We examined B-lymphocyte alloantigens in 41 patients with systemic lupus erythematosus and 184 controls, using a panel of 47 pregnancy serums, and compared reaction frequencies of individual serums. One serum, la-715, reacted with B lymphocytes from 75.6 per cent of patients and 14.1 per cent of controls (Pc less than 0.005, relative risk 18.8). Twenty-eight of the patients were also typed with a panel of HLA-D-related serums from the Seventh International Histocompatibility Workshop, HLA-DRw types assigned, and compared to 490 Workshop controls. Both HLA-DRw2 (57.1 per cent vs. 26.4 per cent, Pc less than 0.004) and HLA-DRw3 (46.4 per cent vs. 22.2 per cent, Pc less than 0.03) were increased in systemic lupus erythematosus. This study demonstrates that select B-lymphocyte alloantigens, which are controlled by genes in the major histocompatibility complex, are present in increased frequency in systemic lupus erythematosus.