Brain-derived neurotrophic factor and epilepsy--a missing link?
Brain-derived neurotrophic factor and epilepsy--a missing link?
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DOI：
10.1111/j.1535-7511.2005.05312.x
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发表时间：
2005-05-01
影响因子：
3.6
通讯作者：
Scharfman, Helen E
中科院分区：
文献类型：
--
作者：
Scharfman, Helen E
众所周知，脑源性神经营养因子(BDNF)对中枢神经系统的正常发育至关重要，最近的研究也证明了BDNF能够改变成人中枢神经系统的结构和功能。因此，BDNF与癫痫等疾病有关也就不足为奇了，这些疾病可能涉及大脑皮质发育异常或成熟后大脑结构和功能改变。该综述评价了BDNF在颞叶癫痫(TLE)发病中的作用的证据，特别是最近的研究。
It has been known for some time that brain-derived neurotrophic factor (BDNF) is critical to normal development of the CNS, and more recently, studies also have documented the ability of BDNF to modify adult CNS structure and function. Therefore, it is no surprise that BDNF has been linked to diseases, such as epilepsy, which may involve abnormal cortical development or altered brain structure and function after maturity. This review evaluates the evidence, particularly from recent studies, that BDNF contributes to the development of temporal lobe epilepsy (TLE).