Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts.
Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts.
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DOI：
10.4049/jimmunol.1500669
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发表时间：
2015-07-01
期刊：
影响因子：
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通讯作者：
Jakubzick CV
中科院分区：
文献类型：
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作者：
Atif SM;Nelsen MK;Gibbings SL;Desch AN;Kedl RM;Gill RG;Marrack P;Murphy KM;Grazia TJ;Henson PM;Jakubzick CV
在移植中，mhc匹配个体接受移植物的主要障碍是次要组织相容性Ags的不匹配。次要组织相容性Ags是由多态蛋白衍生的肽，可以通过apc在MHC分子上呈现。APC亚型是引起轻微ag错配移植物排斥反应的唯一原因，目前尚未确定。在这项研究中，我们研究了三种小鼠模型的移植排斥反应：1)男性特异性小Ags错配，2)与男性特异性小Ags不同的小Ags错配，3)皮肤移植。这项研究表明，在缺乏病原体相关分子模式的情况下，batf3依赖性树突状细胞会引起表达不匹配的次要Ags的细胞和移植物的排斥反应。我们的发现在临床移植中可能具有重要意义，因为微小的银反应性与多个同种异体移植组织的发病机制有关。
In transplantation, a major obstacle for graft acceptance in MHC-matched individuals is the mismatch of minor histocompatibility Ags. Minor histocompatibility Ags are peptides derived from polymorphic proteins that can be presented by APCs on MHC molecules. The APC subtype uniquely responsible for the rejection of minor Ag–mismatched grafts has not yet been identified. In this study, we examined graft rejection in three mouse models: 1) mismatch of male-specific minor Ags, 2) mismatch of minor Ags distinct from male-specific minor Ags, and 3) skin transplant. This study demonstrates that in the absence of pathogen-associated molecular patterns, Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor Ags. The implication of our findings in clinical transplantation may be significant, as minor Ag reactivity has been implicated in the pathogenesis of multiple allograft tissues.