Three-part inventions: Intracellular signaling and induced proximity
Three-part inventions: Intracellular signaling and induced proximity
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DOI：
10.1016/s0968-0004(96)20027-1
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发表时间：
1996-11-01
影响因子：
13.8
通讯作者：
Schreiber, SL
中科院分区：
文献类型：
--
作者：
Crabtree, GR;Schreiber, SL
每个人都有生火的经验;把原木放在一起会使火焰从之前熄灭的余烬中出现。类似地，仅仅是接近就可能介导定性的生物反应。我们讨论了自然分子，似乎已经出现了两种蛋白质在一起，并说明如何使用这种简单的机制来控制各种各样的生物过程。
Everyone has had the experience of stoking a fire; putting the logs close together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological responses. We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.