The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes
The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes
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DOI：
10.1016/j.clinph.2015.04.053
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发表时间：
2016-01-01
影响因子：
4.7
通讯作者：
Kobayashi, Katsuhiro
中科院分区：
文献类型：
--
作者：
Jacobs, Julia;Vogt, Christina;Kobayashi, Katsuhiro
目的：间期高频振荡（HFOs, 80 ~ 500 Hz）可预测癫痫发作区（SOZ），但视觉检测HFOs耗时长。时频分析可以揭示与间隔尖峰相关的大高频（HF）功率变化（80- 500hz）。本研究确定了hfo的速率和与峰值相关的HF功率变化与SOZ共定位的程度。方法：对14例颅内脑电图记录患者的583个通道（其中SOZ区68个通道）进行分析。我们确定在SOZ和非SOZ中，视觉标记的hfo率和峰值相关的HF功率变化是否不同。结果：SOZ组hfo发生率明显高于SOZ组。在SOZ和非SOZ中，与峰值相关的高频功率增强程度没有差异，而在SOZ中，峰值后的高频功率衰减明显比非SOZ中更严重。在7/14的患者中，显示hfo和大峰值相关hf变化的区域在分布上部分重叠。结论：在尖峰时，高频增强和高高频fo发生率发生在不同的大脑位置。hfo对SOZ的识别效果最好。尖峰后高频功率衰减可能表示这些通道中抑制作用的增加，应进一步研究。意义：尖峰和hfo期间的强高频功率变化似乎反映了不同的现象。(C) 2015年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Interictal high-frequency oscillations (HFOs, 80-500 Hz) can predict the seizure onset zone (SOZ), but visual detection of HFOs is time consuming. Time-frequency analysis can reveal large high-frequency (HF) power changes (80-500 Hz) associated with inter-ictal spikes. The present study determines how well the rate of HFOs and spike-related HF power changes were co-localized with SOZ.Methods: We analyzed 583 channels (68 in the SOZ) sampled from 14 patients who underwent intracranial EEG recording. We determined if the rate of visually-marked HFOs and spike-related HF power changes differed between SOZ and non-SOZ.Results: Significantly higher rates of HFOs were found in SOZ. The degree of spike-related HF power augmentation failed to differ between SOZ and non-SOZ, whereas that of post-spike HF power attenuation was significantly more severe in SOZ compared to in non-SOZ. Regions showing HFOs and large spike-related HF-changes showed a partial overlap in distribution in 7/14 patients.Conclusions: Strong HF augmentation during spikes and high HFO rates occurred over different brain locations. The rate of HFOs showed the best performance in identifying SOZ. Post-spike HF power attenuation may represent increased inhibition in these channels and should be investigated further.Significance: Strong HF power changes during spikes and HFOs per se seem to reflect distinct phenomena. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.