EFFECT OF DIET-INDUCED WEIGHT-LOSS ON TOTAL-BODY BONE MASS
EFFECT OF DIET-INDUCED WEIGHT-LOSS ON TOTAL-BODY BONE MASS
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DOI：
10.1042/cs0820429
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发表时间：
1992-04-01
期刊：
影响因子：
6
通讯作者：
KREITZMAN, S
中科院分区：
文献类型：
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作者：
COMPSTON, JE;LASKEY, MA;KREITZMAN, S
1. 在极低热量饮食[405 kcal（1701 kJ）/天]之前和之后10周，通过双能X射线吸收法测量8名女性的全身面积骨密度. 平均体重减轻15.6 kg，全身骨密度从1.205 +/- 0.056降至1.175 +/- 0.058 g/cm 2（平均值+/- SD，P < 0.005）。 停止饮食后，体重逐渐增加，到10个月时与基线值相似。 停止饮食后全身骨密度也增加，饮食后10个月获得的平均值与初始值没有显着差异。 在整个研究过程中，所有受试者的全身骨矿物质密度值均在正常受试者报告的范围内。 这些数据表明，饮食诱导的体重减轻与快速骨丢失有关，随后的体重增加伴随着骨量增加。 需要进一步的研究来确定这些发现的临床意义，特别是骨丢失的骨骼分布。
1. Total body areal bone mineral density was measured by dual-energy X-ray absorptiometry in eight women before and 10 weeks after a very-low-calorie diet [405 kcal (1701 kJ)/day].2. The mean weight loss of 15.6 kg was accompanied by a statistically significant reduction in total body bone mineral density from 1.205 +/- 0.056 to 1.175 +/- 0.058 g/cm2 (mean +/- SD, P < 0.005).3. After cessation of the diet, weight gradually increased and by 10 months was similar to baseline values. Total body bone mineral density also increased after stopping the diet and mean values obtained 10 months after the diet did not differ significantly from initial values. Throughout the study total body bone mineral density values in all subjects were well within the range reported for normal subjects.4. These data indicate that diet-induced weight loss is associated with rapid bone loss, subsequent weight gain being accompanied by increases in bone mass. Further studies are required to establish the clinical significance of these findings and, in particular, the skeletal distribution of bone loss.