Interplay between intercellular signaling and cell movement in development
Interplay between intercellular signaling and cell movement in development
复制标题
发育过程中细胞间信号传导与细胞运动之间的相互作用
DOI：
10.1016/j.semcdb.2014.05.011
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发表时间：
2014
影响因子：
7.3
通讯作者：
Luis G. Morelli and Andrew C. Oates
中科院分区：
文献类型：
--
作者：
Koichiro Uriu;Luis G. Morelli and Andrew C. Oates
细胞运动和局部细胞间信号是动物发育过程中形态发生的重要组成部分。细胞间信号通过细胞与细胞的直接接触调节细胞群体的集体运动。相反，细胞运动可以通过重新排列相邻细胞来影响局部细胞间信号传递。在这里，我们首先讨论细胞间信号如何在发育过程中调节集体细胞运动的理论模型。例子包括神经脊细胞迁移、汇聚性伸展和脊椎轴伸长过程中的细胞运动。其次，我们回顾了细胞运动如何影响细胞间信号传递的理论研究，并以斑马鱼的分段时钟为例。我们建议，在研究胚胎发育中的形态发生时，必须考虑细胞运动和细胞间信号之间的相互作用。
Cell movement and local intercellular signaling are crucial components of morphogenesis during animal development. Intercellular signaling regulates the collective movement of a cell population via direct cell-cell contact. Cell movement, conversely, can influence local intercellular signaling by rearranging neighboring cells. Here, we first discuss theoretical models that address how intercellular signaling regulates collective cell movement during development. Examples include neural crest cell migration, convergent extension, and cell movement during vertebrate axis elongation. Second, we review theoretical studies on how cell movement may affect intercellular signaling, using the segmentation clock in zebrafish as an example. We propose that interplay between cell movement and intercellular signaling must be considered when studying morphogenesis in embryonic development.© 2014 Elsevier Ltd.