Endothelial progenitor cells=EPC=elemental pernicious complexity.
Endothelial progenitor cells=EPC=elemental pernicious complexity.
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内皮祖细胞=EPC=基本有害复杂性。
DOI：
10.1089/ars.2010.3803
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发表时间：
2011
影响因子：
6.6
通讯作者：
Ushio-Fukai,Masuko
中科院分区：
文献类型：
--
作者：
Brandes,RalfP;Ushio-Fukai,Masuko
内皮祖细胞（EPCs）是一种具有促血管生成潜能的异质细胞群，它们不仅来自骨髓，也来自其他组织。根据使用的模型和细胞类型，促血管生成效应是直接血管整合的结果，生长因子和细胞因子的旁分泌释放，或与其他细胞成分（如单核细胞或血小板）的复杂相互作用。内皮祖细胞的促血管生成潜力取决于所研究的内皮祖细胞的特定类型，并受患者的风险和生活方式因素以及决定病变组织和内皮祖细胞蛋白质组归巢的局部因素的调节。在这个关于EPCs的论坛上，这些方面将在单独的综述文章中进行介绍，并伴随着两项关于NADPH氧化酶在EPC动员中的作用和有机硝酸盐对EPCs的影响的原创研究。氧化还原信号，15,11 - 9。
Endothelial progenitor cells (EPCs) represent a heterogeneous population of cells with a pro-angiogenic potential that are derived not only from bone marrow but also from other tissues. Depending on the model and cell type used, the pro-angiogenic effect is a consequence of direct vascular integration, the paracrine release of growth factors and cytokines, or complex interactions with other cellular components like monocytes or platelets. The pro-angiogenic potential of EPCs is dependent on the particular type of EPC studied and modulated by the risk and life style factors of the patient as well as by local factors determining the homing to diseased tissue and the EPC proteome. In this Forum on EPCs these aspects will be covered in individual review articles, which are accompanied by two original research studies on the role of NADPH oxidases for EPC mobilization and the impact of organic nitrates on EPCs.Antioxid. Redox Signal.15, 911–914.