The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation.
The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation.
复制标题
组蛋白甲基转移酶 WHSC1 受 EZH2 调节，对卵巢透明细胞癌细胞增殖很重要。
DOI：
10.1111/jog.14014
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Osuga Y.
中科院分区：
文献类型：
--
作者：
Tsuruga T;Hirata T;Akiyama I;Matsumoto Y;Oda K;Fujii T;Osuga Y.
腹壁子宫内膜异位症中，腹腔镜口部位子宫内膜异位症较少见，腹壁子宫内膜异位症恶变较少见。我们报告一例混合子宫内膜样癌和透明细胞癌起源于子宫内膜异位症。患者为49岁女性，有腹腔镜卵巢子宫内膜异位症切除术病史。体格检查显示腹腔镜术后疤痕周围有皮下实体瘤。影像显示有可疑的恶性肿瘤。她接受了腹壁肿瘤的根治性边缘切除，腹壁皮瓣重建术，子宫切除术，双侧输卵管卵巢切除术和大网膜活检。组织学检查显示子宫内膜样癌和透明细胞癌混合型。计算机断层扫描显示，在六个周期的化疗后没有复发的证据。这是首例腹腔镜下套管针部位子宫内膜异位症恶变病例。
Laparoscopic port site endometriosis is less common in abdominal wall endometriosis, and malignant transformation of abdominal wall endometriosis is rare. We reported a case of mixed endometrioid and clear cell carcinoma arising from port site endometriosis. The patient was a 49‐year‐old woman with a history of laparoscopic excision of ovarian endometrioma. Physical examination revealed a subcutaneous solid tumor around the laparoscopic surgical scar. Imaging showed a suspicious malignancy. She underwent radical marginal resection of the abdominal wall tumor, flap reconstruction of the abdominal wall, hysterectomy, bilateral salpingo‐oophorectomy and omental biopsy. Histological examination revealed mixed endometrioid and clear cell carcinoma. Computed tomography scan showed no evidence of recurrence after six cycles of chemotherapy. This is the first case of malignant transformation from laparoscopic trocar site endometriosis.