Emerging Complexities in Adipocyte Origins and Identity.
Emerging Complexities in Adipocyte Origins and Identity.
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DOI：
10.1016/j.tcb.2016.01.004
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发表时间：
2016-05
影响因子：
19
通讯作者：
Guertin DA
中科院分区：
文献类型：
--
作者：
Sanchez-Gurmaches J;Hung CM;Guertin DA
肥胖及其合并症的全球发病率持续沿着对新型治疗干预的需求。棕色脂肪组织（BAT）作为治疗靶点引起了人们的注意，因为它存在于成年人中，并且在受到刺激时具有高的能量耗散能力，从而燃烧多余的卡路里。治疗干预的另一个潜在途径是在白色脂肪组织（WAT）内诱导称为brite（白色中的棕色样脂肪细胞）或米色脂肪细胞的棕色样脂肪细胞的形成。然而，了解如何利用这些产热细胞的潜力需要深入了解它们的发育起源和调控。最近的细胞标记和谱系追踪实验开始阐明这一新兴领域的脂肪细胞生物学。在这里，我们回顾脂肪细胞的发展，特别注意产热脂肪细胞。
The global incidence of obesity and its comorbidities continues to rise along with a demand for novel therapeutic interventions. Brown adipose tissue (BAT) is attracting attention as a therapeutic target because of its presence in adult humans and high capacity to dissipate energy as heat, and thus burn excess calories, when stimulated. Another potential avenue for therapeutic intervention is to induce, within white adipose tissue (WAT), the formation of brown-like adipocytes called brite (brown-like-in-white) or beige adipocytes. However, understanding how to harness the potential of these thermogenic cells requires a deep understanding of their developmental origins and regulation. Recent cell labeling and lineage tracing experiments are beginning to shed light on this emerging area of adipocyte biology. Here, we review adipocyte development giving particular attention to thermogenic adipocytes.