A simple-to-use tool for predicting response to peginterferon in HBV DNA suppressed chronic hepatitis B patients in China
A simple-to-use tool for predicting response to peginterferon in HBV DNA suppressed chronic hepatitis B patients in China
复制标题
一种简单易用的工具，可预测中国 HBV DNA 受到抑制的慢性乙型肝炎患者对聚乙二醇干扰素的反应
DOI：
10.1016/j.antiviral.2021.105163
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发表时间：
2021-08-12
影响因子：
7.6
通讯作者：
Xie, Qing
中科院分区：
文献类型：
--
作者：
Ren, Peipei;Li, Hu;Xie, Qing
背景：合理应用聚乙二醇干扰素可显著降低血清HBsAg水平，提高HBsAg丢失率。考虑到聚乙二醇干扰素的高成本和药物不良反应，我们旨在开发一个简单易用的评分系统，在治疗早期预测低HBsAg水平或HBsAg清除在病毒学抑制慢性B（CH B）患者治疗结束时。研究方法：从2012年1月至2017年6月，这两个三级中心招募了NA（核苷/核苷酸类似物）诱导的病毒学抑制的非乙型肝炎患者，这些患者通过添加或转换为聚乙二醇干扰素>= 48周开始治疗。回顾性实验确定了320名合适的患者，包括192名训练组和128名验证组。结果如下：使用逻辑回归，在训练队列中开发了一个简单易用的评分系统，该系统将第12周的基线HBsAg水平0.5 log和第12周的ALT爆发整合在一起，并可用于预测HBsAg
Background: Rational administration of peginterferon can remarkably reduce serum HBsAg level and improve the rate of HBsAg loss. Considering the high cost and adverse drug reaction of peginterferon, we aimed to develop a simple-to-use scoring system at early stage of treatment to predict low HBsAg level or HBsAg clearance at the end of treatment in virological suppression chronic hepatitis B (CHB) patients. Methods: Non-cirrhotic CHB patients with NA (nucleoside/nucleotide analogues)-induced virological suppression initiated either by add-on or switch-to peginterferon for >= 48 weeks were enrolled from January 2012 to June 2017 in these two tertiary centers. The retrospective experiment identified 320 suitable patients, including 192 in training and 128 in validation cohorts. Results: Using logistic regression, a simple-to-use scoring system integrating baseline HBsAg level 0.5 log at week 12 and ALT flare at week 12 was developed in the training cohort and good for predicting HBsAg