Familial risk of cancer by site and histopathology
Familial risk of cancer by site and histopathology
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DOI：
10.1002/ijc.10764
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发表时间：
2003-01-01
影响因子：
6.4
通讯作者：
Lit, XJ
中科院分区：
文献类型：
--
作者：
Hemminki, K;Lit, XJ
组织病理学特异性癌症的家族风险尚未确定。我们使用全国范围内的瑞典家族癌症数据库，对1020万个体和100万肿瘤进行分析，以计算0至66岁后代中特定组织学和形态学家族性癌症的标准化发病率（SIR）。我们对后代和父母都使用了组织学编码，但由于病例数量有限，形态学特异性分类只能用于后代，因为父母的所有部位特异性癌症，导致风险估计过高。除了一些已知的相关性外，在家族性风险的组织病理学特异性分析中出现了许多新的发现。总体而言，特定组织学显示所有癌症的SIR为2.07，而任何组织学的SIR为2.00。然而，小的影响是由于乳腺癌和前列腺癌，这表明特定组织学的影响可以忽略不计。卵巢浆液性乳头状囊腺癌、甲状腺乳头状癌和低级别星形细胞瘤的家族风险超过4.0。印戒胃癌、各种形式的卵巢癌和鳞状细胞皮肤癌的家族风险超过3.0。同样值得注意的是肝细胞癌（2.48），胰腺癌（1.92），肺大细胞癌和腺癌（分别为2.29和2.18）和肾透明细胞癌（2.73）的家族风险。许多发现是新的，只能通过应用特定的组织病理学代码来揭示。这些数据要求更密切地描述家族聚集和探索潜在的遗传机制。(C)2002 Wiley-Liss，Inc.
Familial risks for histopathology-specific cancers have not been determined. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and I million tumors to calculate standardized incidence ratios (SIRs) for familial cancers of specific histology and morphology among 0- to 66-year-old offspring. We used histology codes for both offspring and parents, but because of the limited number of cases, the morphology-specific classification could be used only for offspring by all site-specific cancers in parents, resulting in inflated risk estimates. A number of novel findings emerged in the histopathology-specific analysis of familial risks, in addition to some known associations. Overall, specific histology showed an SIR of 2.07 for all cancers compared to an SIR of 2.00 for any histology. However, the small effect was due to breast and prostate cancers, which showed a negligible effect of specific histology. Familial risks of over 4.0 were found for serous papillary cystadenocarcinoma of the ovary, papillary thyroid cancer and low-grade astrocytoma. Familial risks of over 3.0 were found for signet-ring gastric cancer, various forms of ovarian cancer and squamous cell skin cancer. Also noteworthy were familial risks of hepatocellular carcinoma (2.48), pancreatic adenocarcinoma (1.92), large cell carcinoma and adenocarcinoma of the lung (2.29 and 2.18, respectively) and clear cell carcinoma of the kidney (2.73). Many of the findings were novel and could be revealed only by applying codes for specific histopathology. These data call for a closer description of familial aggregations and probing for the underlying genetic mechanisms. (C) 2002 Wiley-Liss, Inc.