Standard reporting requirements for biological samples in metabolomics experiments: mammalian/in vivo experiments
Standard reporting requirements for biological samples in metabolomics experiments: mammalian/in vivo experiments
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DOI：
10.1007/s11306-007-0077-z
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发表时间：
2007-09-01
期刊：
影响因子：
3.6
通讯作者：
Robertson, Donald
中科院分区：
文献类型：
--
作者：
Griffin, Julian L.;Nicholls, Andrew W.;Robertson, Donald
随着代谢组学数据产量的增加，人们意识到需要对这些数据进行标准化描述，以帮助评估、交换、存储和管理代谢组学研究的信息。在本手稿中，描述了涉及哺乳动物受试者的代谢组学研究的生物学背景描述的最低要求的初稿。该建议由代谢组学标准倡议-马米利亚环境工作小组（MSI-MCWSG）提出，作为代谢组学协会领导的更广泛的标准化倡议的一部分。考虑的实验包括功能基因组学研究，药物毒理学，营养基因组学，临床试验和其他人类研究。描述了临床前（例如功能基因组学、毒理学）和临床（例如临床试验、营养基因组学）研究的两项报告要求。据计划，这将导致开发一个用于描述代谢组学实验的工具，使大量数据的存储，检索和操作成为可能。这将有利于评估和传播哺乳动物研究的代谢组学数据。
With the increasing production of metabolomic data there is an awareness of a need for a standardised description of this data to aid assessment, exchange, storage and curation of information from metabolomic studies. In this manuscript the first draft of a minimum requirement for the description of the biological context of a metabolomic study involving mammalian subjects is described. This recommendation has been produced by the Metabolomics Standards Initiative-Maminalian Context Working Sub-Group (MSI-MCWSG) as part of the wider standardisation initiative led by the Metabolomics society. The experiments considered include functional genomic studies, drug toxicology, nutrigenomics, clinical trials, and other human studies. Two reporting requirements are described for pre-clinical (e.g. functional genomics, toxicology) and clinical (e.g. clinical trials, nutrigenomics) studies. It is planned that this will lead to the development of a too] for the description of metabolomic experiments that enables storage, retrieval and manipulation of large amounts of data. This will benefit the assessment and dissemination of metabolomic data from mammalian studies.