Effects of a typical and an atypical antipsychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain
Effects of a typical and an atypical antipsychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain
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DOI：
10.1037/0735-7044.119.4.1052
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发表时间：
2005-08-01
影响因子：
1.9
通讯作者：
Tayler, JE
中科院分区：
文献类型：
--
作者：
Conti, LH;Costill, JE;Tayler, JE
雄性Wistar-Kyoto（WKY）和Brown Norway（BN）大鼠（11-12周，n = 184）接受生理盐水、氟哌啶醇或氯氮平注射，随后脑室内输注生理盐水或促肾上腺皮质激素释放因子（CRF）。测试大鼠的声惊吓反应的前脉冲抑制（PPI）。BN大鼠的PPI低于WKY大鼠，单独使用抗精神病药物均不能增强PPI。在WKY大鼠中，氟哌啶醇和氯氮平均减弱CRF诱导的PPI降低。在CRF治疗的BN大鼠中，氯氮平增强PPI。氯氮平引起的惊吓幅度减少，CRF治疗的BN大鼠，但没有在CRF治疗的WKY大鼠。虽然外源性CRF给药引起的PPI中断可以通过急性抗精神病药物治疗逆转，但基线PPI没有改变。
Male Wistar-Kyoto (WKY) and Brown Norway (BN) rats (11-12 weeks, n = 184) received an injection of saline, haloperidol, or clozapine, followed by an intracerebroventricular infusion of saline or corticotropin-releasing factor (CRF). Rats were tested for prepulse inhibition (PPI) of the acoustic startle response. BN rats showed less PPI than WKY rats, and neither antipsychotic alone enhanced PPI. In WKY rats, both haloperidol and clozapine attenuated the CRF-induced decrease in PPI. In CRF-treated BN rats, clozapine-enhanced PPI. A clozapine-induced decrease in startle amplitude was seen in CRF-treated BN rats but not in CRF-treated WKY rats. Although the disruption of PPI caused by exogenous CRF administration can be reversed by acute antipsychotic treatment, baseline PPI is not altered.