The isoflavone fraction from soybean presents mRNA maturation inhibition activity
The isoflavone fraction from soybean presents mRNA maturation inhibition activity
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大豆异黄酮组分具有 mRNA 成熟抑制活性
DOI：
10.1080/09168451.2016.1249451
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Masuda S
中科院分区：
文献类型：
--
作者：
Kurata M;Murata Y;Momma K;Fouad Ali Mursi I;Takahashi M;Miyamae Y;Kambe T;Nagao M;Narita H;Shibuya Y;Masuda S
最近的研究结果表明，mRNA剪接抑制剂可以是潜在的抗癌候选物。我们以前建立了一个筛选系统，监测mRNA加工，以确定mRNA加工抑制剂。在许多膳食资源中，大豆组分表现出mRNA加工的抑制作用。这些发现表明，各种饮食来源对mRNA生物合成有影响。
Recent findings indicate that mRNA splicing inhibitors can be potential anticancer candidates. We have previously established a screening system which monitors mRNA processing in order to identify mRNA processing inhibitors. Among a number of dietary resources, isoflavone fractions showed an inhibitory effect of mRNA processing. These findings demonstrate that a variety of dietary sources have an impact on mRNA biogenesis.