Cytokines in the pathogenesis of cancer cachexia
Cytokines in the pathogenesis of cancer cachexia
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DOI：
10.1097/01.mco.0000078983.18774.cc
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发表时间：
2003-07-01
影响因子：
3.1
通讯作者：
López-Soriano, FJ
中科院分区：
文献类型：
--
作者：
Argilés, JM;Busquets, S;López-Soriano, FJ
综述目的本综述的目的是总结和更新不同细胞因子在癌症恶病质发病机制中的作用，并提供基于细胞因子作用的治疗策略。最新发现癌症恶病质是一种以明显体重减轻、厌食、虚弱和贫血为特征的综合征。恶病质状态总是与肿瘤的存在和生长相关，并由于诱导厌食或食物摄入减少而导致营养不良状态。此外，肿瘤和宿主之间对营养物质的竞争导致加速的饥饿状态，从而促进宿主严重的代谢紊乱，包括代谢亢进，从而导致能量效率低下。不同的细胞因子显然与这一过程有关，可能导致厌食、代谢亢进和许多其他代谢异常，例如肌肉蛋白水解和细胞凋亡。 总结 尽管对恶病质因子的研究很久以前就开始了，尽管许多科学和经济努力都致力于其发现，但我们距离了解全部真相还有很长的路要走。然而，在了解不同细胞因子肿瘤坏死因子和 IL-6 的作用方面已经取得了很多进展，特别是在与癌症恶病质相关的肌肉萎缩中，这可能是这种复杂综合征的最具代表性的特征。
Purpose of review The aim of the present review is to summarize and update the role of different cytokines in the pathogenesis of cancer cachexia and to provide therapeutic strategies based on cytokine action.Recent findings Cancer cachexia is a syndrome characterized by a marked weight loss, anorexia, asthenia and anemia. The cachectic state is invariably associated with the presence and growth of the tumor and leads to a malnutrition status due to the induction of anorexia or decreased food intake. In addition, the competition for nutrients between the tumor and the host leads to an accelerated starvation state which promotes severe metabolic disturbances in the host, including hypermetabolism, which leads to an increased energetic inefficiency. Different cytokines are clearly implicated in this process, possibly being responsible for anorexia, hypermetabolism and many other metabolic abnormalities, such as muscle proteolysis and apoptosis.Summary Although the search for the cachectic factor(s) started a long time ago, and although many scientific and economic efforts have been devoted to its discovery, we are still a long way from knowing the whole truth. A lot of progress has been made, however, in understanding the role of different cytokines tumor necrosis factor and IL-6 in particular - in muscle wasting associated with cancer cachexia, perhaps the most paradigmatic feature of this complex syndrome.