Subcellular localization and relevant mechanisms of human cancer‐related micropeptides
Subcellular localization and relevant mechanisms of human cancer‐related micropeptides
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DOI：
10.1096/fj.202301019rr
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发表时间：
2023-11
期刊：
影响因子：
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通讯作者：
Jing Deng;Wenli Xu;Y. Jie;Yutian Chong
中科院分区：
文献类型：
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作者：
Jing Deng;Wenli Xu;Y. Jie;Yutian Chong
高质量测序和生物信息学的快速发展已经使非编码RNA(NcRNAs)是不编码蛋白质的垃圾转录本的论点无效。越来越多的证据表明，ncRNAs中的小开放阅读框(SORF)可以编码100个氨基酸范围内的微肽和多肽。一些微肽已经被表征并被证明在人体生理和病理中具有不同的功能，特别是在癌症中。本文主要综述了编码ncRNA的微肽在不同肿瘤中的最新研究进展，并根据其亚细胞定位对其进行分类，从而为微肽在癌症的早期诊断和预后中的应用以及作为治疗靶点提供理论依据。然而，考虑到微肽的固有特性和检测技术方法的局限性，有必要提供更详细的信息。
Rapid advances in high‐quality sequencing and bioinformatics have invalidated the argument that noncoding RNAs (ncRNAs) are junk transcripts that do not encode proteins. Increasing evidence suggests that small open reading frames (sORFs) in ncRNAs can encode micropeptides and polypeptides within 100 amino acids in length. Several micropeptides have been characterized and proven to have various functions in human physiology and pathology, particularly in cancer. The present review mainly highlights the latest studies on ncRNA‐encoded micropeptides in different cancers and categorizes them based on their subcellular localization, thereby providing a theoretical basis for micropeptide applications in the early diagnosis and prognosis of cancer and as therapeutic targets. However, considering the inherent characteristics of micropeptides and the limitations of the assay technology methods, more detailed information is warranted.