Unconventional NMDA Receptor Signaling
Unconventional NMDA Receptor Signaling
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DOI：
10.1523/jneurosci.1825-17.2017
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发表时间：
2017-11-08
影响因子：
5.3
通讯作者：
Sjostrom, P. Jesper
中科院分区：
文献类型：
--
作者：
Dore, Kim;Stein, Ivar S.;Sjostrom, P. Jesper
在经典观点中，NMDA受体（NMDARs）在突触后膜稳定表达，在那里它们通过Ca2+作用于Hebbian可塑性中的信号重合检测。最近，已经确定nmdar介导的传递可以通过神经活动动态调节。此外，nmdar在突触前被发现，在那里它们不能作为传统的巧合探测器。出乎意料的是，NMDARs也被证明在不需要Ca2+的情况下发出代谢信号。这篇综述强调了关于这些非常规NMDAR作用模式的新发现。
In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity. In addition, NMDARs have been found presynaptically, where they cannot act as conventional coincidence detectors. Unexpectedly, NMDARs have also been shown to signal metabotropically, without the need for Ca2+. This review highlights novel findings concerning these unconventional modes of NMDAR action.