Psychological and Behavioral Responses to Genetic Test Results Indicating Increased Risk of Obesity: Does the Causal Pathway from Gene to Obesity Matter?
Psychological and Behavioral Responses to Genetic Test Results Indicating Increased Risk of Obesity: Does the Causal Pathway from Gene to Obesity Matter?
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DOI：
10.1159/000217794
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发表时间：
2010-01-01
影响因子：
1.7
通讯作者：
Michie, S.
中科院分区：
文献类型：
--
作者：
Sanderson, S. C.;Persky, S.;Michie, S.
背景：常见的肥胖相关基因变异可能通过增加饮食或降低代谢来发挥作用。这种差异可能会影响个体对肥胖基因测试结果的反应。方法：这是一项实验模拟研究：191名参与者被要求想象他们收到了表明高饮食（n = 37）或高代谢（n = 41）肥胖风险的基因测试结果，表明高饮食（n = 35）或高代谢（n = 41）肥胖风险的酶测试结果，或没有风险信息（n = 37）。结果包括感知风险、自我效能（对健康饮食能力的信心）、反应效能（对健康饮食会降低风险的信心）和健康饮食的意愿。结果：肥胖风险信息增加组的感知风险和健康饮食意愿高于无风险信息组（p < 0.01）。测试类型对感知风险（遗传vs酶：3.91 vs 3.55, p = 0.031）和因果途径对担忧（饮食vs代谢：3.33 vs 2.86, p = 0.049）有主要影响，但两种操作对任何其他结果均无影响。结论：个人风险信息表明，肥胖风险的增加可能会增加健康饮食的动机，无论这种风险是遗传的还是非遗传的，或者是通过基于饮食的还是基于代谢的因果途径产生的。版权所有(C) 2009 S. Karger AG，巴塞尔
Background: Common obesity-associated genetic variants may exert their effects through increasing eating or decreasing metabolism. Such differences might influence individual responses to obesity genetic test results. Methods: This was an experimental analogue study: 191 participants were asked to imagine they had received a genetic test result indicating high eating-based (n = 37) or high metabolism-based (n = 41) risk of obesity, an enzyme test result indicating high eating-based (n = 35) or high metabolism-based (n = 41) risk of obesity, or no risk information (n = 37). Outcomes included perceived risk, self-efficacy (confidence in ability to eat healthily), response-efficacy (confidence that eating healthily will reduce risk), and intention to eat healthily. Results: The groups receiving increased obesity risk information reported greater perceived risk and intention to eat healthily than the no risk information group (both p < 0.01). There were main effects of test type on perceived risk (genetic vs. enzyme: 3.91 vs. 3.55, p = 0.031) and of causal pathway on worry (eating vs. metabolism: 3.33 vs. 2.86, p = 0.049), but no effects of either manipulation on any other outcomes. Conclusion: Personal risk information indicating increased obesity risk may increase motivation to eat healthily, regardless of whether the risk is described as genetic or non-genetic or as acting through an eating-based or metabolism-based causal pathway. Copyright (C) 2009 S. Karger AG, Basel