Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut
Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut
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DOI：
10.1007/s00259-004-1670-2
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发表时间：
2005-01-01
影响因子：
9.1
通讯作者：
Oyen, WJG
中科院分区：
文献类型：
--
作者：
de Groot, M;Meeuwis, APW;Oyen, WJG
目的：在进行临床正电子发射断层扫描 (PET) 研究时，经常观察到心肌、胃和肠中非病理性 FDG 摄取增加。这种“生理性”增加的 FDG 摄取与（肿瘤）疾病无关，并且是不需要的，因为它可能会干扰正确的图像读取。我们评估了可能影响这一现象的几个患者相关因素的作用。方法：对转诊至我科进行常规全身 FDG-PET 的 175 名患有恶性疾病的非糖尿病患者进行回顾性评估。记录年龄、血糖水平和禁食期的持续时间。对心肌、肠和胃的FDG摄取进行视觉分级。结果：统计分析显示，心肌、肠和胃的FDG摄取增加与血糖水平、年龄或禁食时间没有显着相关。大多数接受重复 PET 扫描的患者（25 名患者进行 92 次扫描）在连续扫描中显示肠和胃的摄取没有或有轻微变化，而心肌摄取变化更大。结论：年龄、禁食时间和血糖水平不影响生理摄取。然而，胃和肠的摄取似乎存在患者特异性模式。
Purpose: Increased, non-pathological FDG uptake in myocardium, stomach and bowel is frequently observed while performing clinical positron emission tomography (PET) studies. This "physiological" increased FDG uptake is not related to (oncological) disease and is unwanted since it may interfere with correct image reading. We evaluated the role of several patient-related factors that may have an influence on this phenomenon.Methods: One hundred and seventy-five non-diabetic patients with malignant diseases, referred to our department for routine whole-body FDG-PET, were retrospectively evaluated. Age, blood glucose levels and duration of the fasting period were recorded. FDG uptake in myocardium, bowel and stomach was visually graded.Results: Statistical analysis showed that increased FDG uptake in myocardium, bowel and stomach was not significantly correlated to blood glucose level, age or duration of fasting. Most patients who underwent repeated PET scans (92 scans in 25 patients), showed no or minor changes in uptake in bowel and stomach on the consecutive scans, while myocardial uptake was more variable.Conclusion: Age, fasting period and blood glucose levels did not influence physiological uptake. However, there seemed to be a patient- specific pattern for stomach and bowel uptake.