Urinary miRNA-29a-3p levels are associated with metabolic parameters via regulation of IGF1 in patients with metabolic syndrome
Urinary miRNA-29a-3p levels are associated with metabolic parameters via regulation of IGF1 in patients with metabolic syndrome
复制标题
代谢综合征患者尿液 miRNA-29a-3p 水平通过调节 IGF1 与代谢参数相关
DOI：
10.3892/br.2019.1195
复制
发表时间：
2019-04-01
影响因子：
2.3
通讯作者：
Zhou, Jiaqiang
中科院分区：
文献类型：
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作者：
Lin, Xihua;Luo, Cheng;Zhou, Jiaqiang
Circulating microRNAs (miRNAs or miRs) have been demonstrated to serve as diagnostic and prognostic biomarkers in metabolic syndrome (MetS). The role of urinary miRNAs in MetS diagnosis remains unknown. Here, elevated miR-29a-3p levels were observed in urine samples of patients with MetS compared with control subjects using a microarray analysis (n=4/group) and validation via reverse transcription-quantitative polymerase chain reaction (n=40/group). Associations between urinary miR-29a-3p levels and parameters associated with metabolism, such as adiposity, insulin resistance, lipid profiles and hepatic enzymes were further assessed. Multiple linear regression analyses revealed that urinary miR-29a-3p levels were independently correlated with fasting insulin (beta=0.561; P
