Long-Term Risk of Atrial Fibrillation and Stroke in Patients With Atrial Septal Defect Diagnosed in Childhood
Long-Term Risk of Atrial Fibrillation and Stroke in Patients With Atrial Septal Defect Diagnosed in Childhood
复制标题
DOI：
10.1016/j.amjcard.2016.10.015
复制
发表时间：
2017-02-01
影响因子：
2.8
通讯作者：
Hjortdal, Vibeke Elisabeth
中科院分区：
文献类型：
--
作者：
Karunanithi, Zarmiga;Nyboe, Camilla;Hjortdal, Vibeke Elisabeth
本研究的目的是评估18岁前确诊的房间隔缺损(ASD)患者发生房颤(AF)和中风的长期风险。1963年至2011年期间被诊断为自闭症的患者通过丹麦国家登记进行了确认，其中1111人符合纳入标准。每名患者与10名对照组在年龄和性别上进行匹配。用COX比例风险回归分析房颤和卒中的风险。累积发病率使用Fine和Gray竞争风险回归计算。中位随访时间为24年(1~49年)。ASD患者发生房颤的风险显著增加；两者均关闭(调整后的危险比[FIR]18.5，95%可信区间[CI]7.8至44.1，p
The aim of this study was to evaluate the long-term risk of atrial fibrillation (AF) and stroke in patients with atrial septal defect (ASD) diagnosed before the age of 18 years. Patients diagnosed with ASD from 1963 to 2011 were identified through national Danish registers, of which 1,111 fulfilled the inclusion criteria. Each patient was matched with 10 control subjects on age and gender. Risk of AF and stroke was assessed using Cox proportional hazards regression. Cumulative incidences were calculated using Fine and Gray competing risk regression. Median follow-up time was 24 years (range 1 to 49 years). Patients with ASD had a significantly increased risk of AF; both with closure (adjusted hazard ratio [FIR] 18.5, 95% confidence interval [CI] 7.8 to 44.1, p