Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators
Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators
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DOI：
10.1016/j.ajic.2018.02.018
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发表时间：
2018-07-01
影响因子：
4.9
通讯作者：
Heimbuch, Brian K.
中科院分区：
文献类型：
--
作者：
Mills, Devin;Harnish, Delbert A.;Heimbuch, Brian K.
背景资料：N95过滤式面罩呼吸器（FFR）的安全有效去污和重复使用有可能显著延长FFR持有量，缓解因流感大流行或其他大流行事件造成的潜在短缺。紫外线杀菌辐照（UVGI）已被证明可有效净化流感污染的FFR。本研究的目的是建立在过去的研究中，通过评估的UVGI去污效率的流感污染的FFR在污染剂的存在下，使用优化的UVGI dose.Methods：12个样本的15个N95 FFR模型被污染的H1N1流感（面罩和表带），然后覆盖有污染剂人工唾液或人工皮肤油。对于每种污染剂，用1 J/cm（2）UVGI处理3个污染的FFR约1分钟，而其他3个污染的FFR保持未处理。切掉所有受污染的表面并提取病毒。结果：在15个FFR模型中的12个的面罩和15个FFR模型中的7个的条带上观察到两种污染条件下流感病毒存活率的显著降低（>= 3 log）。结论：这些数据表明，使用UVGI对FFR进行去污和重复使用是有效的。UVGI方法的实施需要仔细考虑FFR模型、材料类型和设计。(C)2018感染控制和流行病学专业人员协会，Inc.爱思唯尔公司出版All rights reserved.
Background: Safe and effective decontamination and reuse of N95 filtering facepiece respirators (FFRs) has the potential to significantly extend FFR holdings, mitigating a potential shortage due to an influenza pandemic or other pandemic events. Ultraviolet germicidal irradiation (UVGI) has been shown to be effective for decontaminating influenza-contaminated FFRs. This study aims to build on past research by evaluating the UVGI decontamination efficiency of influenza-contaminated FFRs in the presence of soiling agents using an optimized UVGI dose.Methods: Twelve samples each of 15 N95 FFR models were contaminated with H1N1 influenza (facepiece and strap), then covered with a soiling agent-artificial saliva or artificial skin oil. For each soiling agent, 3 contaminated FFRs were treated with 1 J/cm(2) UVGI for approximately 1 minute, whereas 3 other contaminated FFRs remained untreated. All contaminated surfaces were cut out and virus extracted. Viable influenza was quantified using a median tissue culture infectious dose assay.Results: Significant reductions (>= 3 log) in influenza viability for both soiling conditions were observed on facepieces from 12 of 15 FFR models and straps from 7 of 15 FFR models.Conclusions: These data suggest that FFR decontamination and reuse using UVGI can be effective. Implementation of a UVGI method will require careful consideration of FFR model, material type, and design. (C) 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.