Pontine and basal forebrain transections disinhibit brown fat thermogenesis in neonatal rats.
Pontine and basal forebrain transections disinhibit brown fat thermogenesis in neonatal rats.
复制标题
桥脑和基底前脑横断可抑制新生大鼠棕色脂肪产热。
DOI：
10.1016/0006-8993(95)00908-9
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发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Sokoloff,G
中科院分区：
文献类型：
--
作者：
Blumberg,MS;Schalk,SL;Sokoloff,G
Bignall、Heggeness 和 Palmer (1975) 最先证明新生大鼠脑桥中段横断后代谢产热增加。随后对成年大鼠的研究表明，该过程会抑制棕色脂肪组织 (BAT) 的生热作用。 Bignall 和他的同事还发现，下丘脑消融并没有导致 5 日龄婴儿产热增加，这使他们得出结论，该年龄的体温调节依赖于更多的尾部结构。我们还发现脑桥中段横断会抑制 BAT 生热作用，此外，我们还将这一发现推广到了新生幼犬身上。然而，当在基底前脑进行横切时，我们还发现棕色脂肪产热作用显着而快速地增加。这些结果表明，新生大鼠中存在至少两种抑制 BAT 产热的来源：一种位于中脑头侧脑桥尾侧，另一种位于基底前脑。
Bignall, Heggeness and Palmer (1975) were the first to demonstrate increases in metabolic heat production following midpontine transection in neonatal rats. Subsequent work in adult rats has shown that this procedure disinhibits thermogenesis by brown adipose tissue (BAT). Bignall and his colleagues also found that hypothalamic ablation did not result in increased thermogenesis in 5-day-olds, leading them to conclude that thermoregulation depends on more caudal structures at that age. We have also found that midpontine transection disinhibits BAT thermogenesis and, furthermore, have extended that finding to newborn pups. When transections were made in the basal forebrain, however, we also found profound and rapid increases in brown fat thermogenesis. These results suggest the presence of at least two sources of inhibition of BAT thermogenesis in newborn rats: one located in the rostral pons-caudal midbrain and one located in the basal forebrain.