Neural effects of acute stress on appetite: A magnetoencephalography study
Neural effects of acute stress on appetite: A magnetoencephalography study
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DOI：
10.1371/journal.pone.0228039
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发表时间：
2020-01-22
期刊：
影响因子：
3.7
通讯作者：
Yoshikawa, Takahiro
中科院分区：
文献类型：
--
作者：
Nakamura, Chika;Ishii, Akira;Yoshikawa, Takahiro
压力在现代社会中普遍存在，并且可以通过其对食欲的影响来影响人类健康。因此，在本研究中，我们的目的是澄清急性应激影响禁食期间健康非肥胖男性食欲的神经机制。总共有22名志愿者在不同的日子参加了两个实验（压力和控制条件）。参与者在这两种情况下进行了一项压力诱导的语音和心算任务，然后观看食物的图像，在此期间，他们的神经活动被记录使用脑磁图（MEG）。在应激条件下，参与者被告知在观看食物图像后再次执行言语和心算任务;然而，另一个言语和心算任务实际上没有被执行。然后使用视觉模拟量表评估压力和食欲的主观水平。进行心电图以评估反映交感神经活动的心率变异性指数。研究结果表明，主观水平的压力和交感神经活动的增加，在MEG会议的压力条件下，而食欲逐渐增加的MEG会议只有在控制条件。观察食物图像引起的额极α波段功率的下降在应激条件下比在对照条件下更大。这些结果表明，急性应激可以抑制食欲的增加，这种抑制与额极有关。本研究结果可能为进一步了解急性应激影响食欲的神经机制提供有价值的线索。然而，由于本研究中所研究的压力与即将到来的压力事件的预期有关，我们的研究结果可能无法推广到与即将到来的压力事件的预期无关的压力。
Stress is prevalent in modern society and can affect human health through its effects on appetite. Therefore, in the present study, we aimed to clarify the neural mechanisms by which acute stress affects appetite in healthy, non-obese males during fasting. In total, 22 volunteers participated in two experiments (stress and control conditions) on different days. The participants performed a stress-inducing speech-and-mental-arithmetic task under both conditions, and then viewed images of food, during which, their neural activity was recorded using magnetoencephalography (MEG). In the stress condition, the participants were told to perform the speech-and-mental-arithmetic task again subsequently to viewing the food images; however, another speech-and-mental-arithmetic task was not performed actually. Subjective levels of stress and appetite were then assessed using a visual analog scale. Electrocardiography was performed to assess the index of heart rate variability reflecting sympathetic nerve activity. The findings showed that subjective levels of stress and sympathetic nerve activity were increased in the MEG session in the stress condition, whereas appetite gradually increased in the MEG session only in the control condition. The decrease in alpha band power in the frontal pole caused by viewing the food images was greater in the stress condition than in the control condition. These findings suggest that acute stress can suppress the increase of appetite, and this suppression is associated with the frontal pole. The results of the present study may provide valuable clues to gain a further understanding of the neural mechanisms by which acute stress affects appetite. However, since the stress examined in the present study was related to the expectation of forthcoming stressful event, our present findings may not be generalized to the stress unrelated to the expectation of forthcoming stressful event.