Cognitive operations in the human caudate nucleus
Cognitive operations in the human caudate nucleus
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DOI：
10.1016/s0304-3940(97)00680-0
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发表时间：
1997-10-03
影响因子：
2.5
通讯作者：
Melnichuk, KV
中科院分区：
文献类型：
--
作者：
Abdullaev, YG;Melnichuk, KV
本文通过记录帕金森病患者尾状核头部神经元的深部电极活动，探讨了尾状核头部在词汇判断、语义分类、阅读、记忆提取和物体命名等任务中的作用。当需要语义处理时，细胞的放电率在400-600 ms内增加，语音差异使放电从1000 ms增加到1200 ms。这些反应与先前在Broca区描述的反应相似。这两个阅读大声和外显记忆提取任务引发了抑制在发射相同的细胞与发病约800毫秒。结果证实了早期的损伤和刺激的研究，并提供了一个基础，有关细胞活动的研究，血流和头皮电活动在类似的认知任务，从而帮助我们了解参与人类认知的细胞机制。(C)1997 Elsevier Science爱尔兰有限公司
We have addressed the role of the head of caudate nucleus in tasks of lexical decision, semantic categorization, reading aloud, memory retrieval and object naming by recording neuronal activity from depth electrodes in parkinsonism patients. The firing rate of cells was increased within 400-600 ms when semantic processing was required, Phonological differences increased firing from 1000 to 1200 ms. These responses were similar to those described earlier in Broca's area. Both reading aloud and explicit memory retrieval tasks elicited an inhibition in firing of the same cells with an onset around 800 ms. The results confirm earlier lesion and stimulation studies, and provide a basis for relating cellular activity to studies of blood flow and scalp electrical activity in similar cognitive tasks thus helping us to understand the cellular mechanisms involved in human cognition. (C) 1997 Elsevier Science Ireland Ltd.