Antitumor activity of selective hyperthermia in tumor-bearing rats using thermosensitive magnetoliposomes as a new hyperthermic material
Antitumor activity of selective hyperthermia in tumor-bearing rats using thermosensitive magnetoliposomes as a new hyperthermic material
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热敏磁脂质体作为新型热疗材料对荷瘤大鼠选择性热疗的抗肿瘤活性
DOI：
10.3109/10717549709033186
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发表时间：
1997
期刊：
影响因子：
6
通讯作者：
J. Weinstein
中科院分区：
文献类型：
--
作者：
Y. Masuko;K. Tazawa;Hitoshi Sato;E. Viroonchatapan;S. Takemori;Tetsurō Shimizu;H. Ohkami;H. Nagae;M. Fujimaki;I. Horikoshi;J. Weinstein
本文研究了一种新型热疗材料-葡聚糖磁性（DM）热敏脂质体（TM）对大鼠AH 60 C肿瘤的抗肿瘤活性。将TM以15 mg/cm 3肿瘤的铁浓度注射到皮下放置在Donryu大鼠背部的AH 60 C肿瘤中。注射后，将大鼠（给药组）全身暴露于感应加热产生的500 kHz电磁场。治疗组进一步分为一次和两次治疗组，以检查是否重复高热是可能的后，一个单一的TM注射。对照组也接受TM注射，但不接受高温治疗。在加热组中，肿瘤内的温度在7分钟内显著升高至42°C，但周围组织未被加热。治疗组对AH 60 C肿瘤生长的抑制作用明显高于对照组（P <0.05）。01）。史托洛...
AbstractThe antitumor activity of dextran magnetite (DM)-incorporating thermosensitive liposomes, namely thermosensitive magnetoliposomes (TMs), as a new hyperthermic material was examined in rats bearing AH60C tumors. TMs were injected at an iron concentration of 15 mg per cm3 tumor into AH60C tumors placed subcutaneously in the backs of Donryu rats. After injection, the whole body of the rat (treated group) was exposed to a 500-kHz electromagnetic field generated by inductive heating. The treated group was further divided into once- and twice-treated groups in order to examine whether repetitive hyperthermia is possible after a single TM injection. A control group also received a TM injection but was not treated with hyperthermia. In the heated groups, there was a marked temperature rise inside the tumor up to 42°C within 7 min, but surrounding tissues were not heated. The inhibition of the growth of AH60C tumor in the treated groups was significantly greater than in the control group (P <. 01). Histolo...