Genome-wide association study identifies five loci associated with lung function
Genome-wide association study identifies five loci associated with lung function
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DOI：
10.1038/ng.501
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发表时间：
2010-01-01
期刊：
影响因子：
30.8
通讯作者：
Tobin, Martin D.
中科院分区：
文献类型：
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作者：
Repapi, Emmanouela;Sayers, Ian;Tobin, Martin D.
肺功能指标是预测发病率和死亡率并定义慢性阻塞性肺疾病（COPD）的遗传特征。我们在SpiroMeta联盟（n = 20，288名欧洲血统的个体）中测试了全基因组与1秒用力呼气量（FEV1）以及FEV1与用力肺活量（FVC）的比值的相关性。我们对直接基因分型的数据进行了顶级信号的荟萃分析（n
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n