New encouraging developments in contact prediction: Assessment of the CASP11 results.
New encouraging developments in contact prediction: Assessment of the CASP11 results.
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DOI：
10.1002/prot.24943
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发表时间：
2016-09
期刊：
影响因子：
2.9
通讯作者：
Kryshtafovych A
中科院分区：
文献类型：
--
作者：
Monastyrskyy B;D'Andrea D;Fidelis K;Tramontano A;Kryshtafovych A
本文提供了一份报告的国家的最先进的预测分子内残基接触的蛋白质的基础上提交给CASP 11实验的预测评估。评估的重点放在预测远距离接触的准确性上。29个小组参与了CASP 11的接触预测。其中至少有8个使用了最近开发的进化偶联技术，其中最高的一组（CONSIP 2）对无法通过同源性建模的目标蛋白质的精确度达到了27%。这一结果表明，在相关突变方法的基础上发展的方法的突破。接触的成功预测被证明在三维结构建模中实际上是有帮助的;特别是靶T0806被非常好地建模，其准确度对于这种大小（>250个残基）的从头计算靶还没有看到。
This paper provides a report on the state-of-the-art in the prediction of intra-molecular residue-residue contacts in proteins based on the assessment of the predictions submitted to the CASP11 experiment. The assessment emphasis is placed on the accuracy in predicting long-range contacts. Twenty-nine groups participated in contact prediction in CASP11. At least eight of them used the recently developed evolutionary coupling techniques, with the top group (CONSIP2) reaching precision of 27% on target proteins that could not be modeled by homology. This result indicates a breakthrough in the development of methods based on the correlated mutation approach. Successful prediction of contacts was shown to be practically helpful in modeling three-dimensional structures; in particular target T0806 was modeled exceedingly well with accuracy not yet seen for ab initio targets of this size (>250 residues).