Fine structure of neural spiking and synchronization in the presence of conduction delays
Fine structure of neural spiking and synchronization in the presence of conduction delays
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DOI：
10.1073/pnas.95.3.1259
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发表时间：
1998-02-03
影响因子：
11.1
通讯作者：
Kopell, N
中科院分区：
文献类型：
--
作者：
Ermentrout, GB;Kopell, N
产生γ频率节律的兴奋性神经元和抑制性神经元的海马网络显示出这样的行为，即当在分离的部位有强刺激时，抑制性细胞产生尖峰双峰。有人认为，双峰在远距离同步的能力中起着关键作用。该分析描述了两个独立的效应：一个来自于从分离的局部回路到抑制性细胞的兴奋的定时，另一个来自于从分离的局部回路到兴奋性细胞的抑制的定时，我们证明了具有这两种效应的网络与仅具有兴奋性或抑制性耦合类型的网络相比具有不同的同步特性，我们给出了与抑制性相互作用相关的较短空间尺度的基本原理。
Hippocampal networks of excitatory and inhibitory neurons that produce gamma-frequency rhythms display behavior in which the inhibitory cells produce spike doublets when there is strong stimulation at separated sites, It has been suggested that the doublets play a key role in the ability to synchronize over a distance, Here we analyze the mechanisms by which timing in the spike doublet can affect the synchronization process. The analysis describes two independent effects: one comes from the timing of excitation from separated local circuits to an inhibitory cell, and the other comes from the timing of inhibition from separated local circuits to an excitatory cell, We show that a network with both of these effects has different synchronization properties than a network with either excitatory or inhibitory type of coupling alone, and we give a rationale for the shorter space scales associated with inhibitory interactions.